Metal resistance sequences and transgenic plants

Overview

Information

Number
5668294
Application
08/427097
Filing date
04/21/1995
Issue date
09/16/1997
Inventor(s)
Richard B. Meagher, Anne O. Summers
US Classification
435/320.1; 435/468; 435/69.1; 536/23.2; 536/23.7; 536/24.1; 800/278; 800/287; 800/294; 800/298; 800/317
View at USPTO

Citations

Edenspace Systems (1)
B & H Manufacturing (1)
CELLECTIS (1)

Abstract

Abstract

The present invention provides nucleic acid sequences encoding a metal ion resistance protein, which are expressible in plant cells. The metal resistance protein provides for the enzymatic reduction of metal ions including by not limited to divalent Cu, divalent mercury, trivalent gold, divalent cadmium, lead ions and monovalent silver ions. Transgenic plants which express these coding sequences exhibit increased resistance to metal ions in the environment as compared with plants which have not been so genetically modified. Transgenic plants which are resistant to organomercurials including alkylmercury compounds, among others, are provided by the further inclusion of plant-expressible organomercurial lyase coding sequences. Furthermore, these transgenic plants which have been genetically modified to express the metal resistance coding sequences of the present invention can participate in the bioremediation of metal contamination via the enzymatic reduction of metal ions. Transgenic plants resistant to organomercurials can further mediate remediation of alkylmercury compounds in the environment by causing the freeing of mercuric ions and the reduction of the ionic mercury to the less toxic elemental mercury.

Assignees with Similar Patents

BASF Plant Science (45)
Regents of the University of California, The (9)
NA (5)
University of Massachusetts (4)
UNIVERSITY OF GEORGIA, THE (4)

Referenced by

UNIVERSITY OF GEORGIA, THE (4)
Genopsys (3)
bioMerieux (1)
University of Guelph (1)
Savannah River Nuclear Solutions, (1)

Tech Analysis

Class Subclass Type Reference Factor Citation Factor Strength Grant time Early grant (%)
435 320.1 Emerging Average Seminal Medium Average 28.2
435 468 Emerging Average Seminal Medium Average 47.3
435 69.1 Emerging Average Seminal Medium Average 27.8
536 23.2 Emerging Average Seminal Medium Average 34.0
536 23.7 Emerging Average Seminal Medium Average 30.8
536 24.1 Emerging Average Seminal Medium Average 26.3
800 278 Emerging Average Seminal Medium Average 39.3
800 287 Emerging Average Seminal Medium Rapid 20.4
800 294 Emerging Average Seminal Medium Rapid 23.1
800 298 Emerging Average Seminal Medium Average 35.4
800 317 Emerging Average Seminal Medium High Slow 77.7