System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry

Overview

Information

Number
6140639
Application
09/086894
Filing date
05/29/1998
Issue date
10/31/2000
Inventor(s)
Arkady I. Gusev, David M. Hercules
US Classification
250/288
View at USPTO

Citations

Kratos Analytical (2)
Agilent Technologies (1)
Sepragen (1)
Shimadzu (1)
Shionogi & Co. (1)
Hitachi, (1)

Abstract

Abstract

The invention relates to a system and method for on-line coupling of liquid capillary separation with matrix-assisted laser desorption ionization mass spectrometric analysis. In this system and method, analyte from liquid capillary separation is mixed with matrix molecules for matrix-assisted laser desorption ionization. Continuous flow of the analyte/matrix combined with vacuum conditions allows evaporation and crystallization of homogeneous samples on a solid sample surface. Dual use of laser irradiation to desorb/ionize and remove excess sample facilitates on-line use and automation.

Assignees with Similar Patents

Baylor College Of Medicine (15)
Agilent Technologies (9)
Science & Engineering Services (6)
NA (5)
Waters (4)

Referenced by

Agilent Technologies (7)
Ut-Battelle, (6)
Hitachi, (2)
UNIVERSITY OF TENNESSEE RESEARCH (2)
LEAR (1)
Yasumi Capital, (1)
Waters (1)
LI, LIANG (1)
GEORG-AUGUST-UNIVERSITAT GOETTINGEN (1)
Finnigan (1)
SHIMADZU RESEARCH LABORATORY (1)
Syngenta Participations (1)
Vanderbilt University (1)
Shimadzu (1)
zeteo tech (1)
Ionwerks (1)
DH Technologies Development Pte. (1)
Chem-Space Associates (1)

Tech Analysis

Class Subclass Type Reference Factor Citation Factor Strength Grant time Early grant (%)
250 288 Emerging Average Seminal Medium High Average 54.2