Genistein for use in inhibiting osteroclasts

Overview

Information

Number: 5506211
Application: 08/241040
Filing date: 05/09/1994
Issue date: 04/09/1996
Inventor(s): Stephen Barnes, Harry C. Blair

US Classification: 424/439; 424/441; 514/25; 514/27; 514/456; 514/457

Citations

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. (2)

Number	Title	Issue Date
4826963	Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredient	1989/05/02
5043326	Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredients	1991/08/27

Yamanouchi Pharmaceutical Co. (2)

Number	Title	Issue Date
4841077	Isoflavone derivatives, and salts thereof, and cancerocidal and immunosuppressive agents containing the same	1989/06/20
4960908	Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents	1990/10/02

Takeda Chemical Industries, (1)

Number	Title	Issue Date
4644012	Treatment for osteoporosis	1987/02/17

Chinoin Pharmaceutical and Chemical Works (1)

Number	Title	Issue Date
5110720	Dental composition and a process for the preparation thereof	1992/05/05

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt. (1)

Number	Title	Issue Date
4163746	Metabolic 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions containing the same	1979/08/07

ACDS Technologies, (1)

Number	Title	Issue Date
5424331	Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis	1995/06/13

CHINOIN PHARMACEUTICAL AND CHEMICAL AND CO. (1)

Number	Title	Issue Date
5110720	Dental composition and a process for the preparation thereof	1992/05/05

Abstract

Abstract

Disclosed are methods and compositions for use in inhibiting osteoclast activity and, particularly, the osteoclast acid secretion that leads to bone-degradation. It is shown that the isoflavone genistein inhibits the acid secretion of osteoclasts and reduces bone resorption. The present invention thus provides advantageous methods for use in inhibiting osteoclast activity, as may be employed to reduce bone loss, for example, in patients with osteoporosis, metastatic bone cancers and renal failure.

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Referenced by

Archer-Daniels-Midland (18)

Number	Title	Issue Date
5702752	Production of isoflavone enriched fractions from soy protein extracts	1997/12/30
6680381	Recovery of isoflavones from soy molasses	2004/01/20
6706292	Recovery of isoflavones from soy molasses	2004/03/16
6900240	Method of preparing and using compositions extracted from vegetable matter for the treatment of cancer	2005/05/31
7285297	Method of reducing low density liproprotein cholesterol concentration	2007/10/23
6664382	Recovery of isoflavones from soy molasses	2003/12/16
5792503	Production of isoflavone enriched fractions from soy protein extracts	1998/08/11
6001368	Method for inhibiting or reducing the risk of macular degeneration	1999/12/14
6015785	Aglucone isofavone enriched vegetable protein extract and isolate and process for producing	2000/01/18
6083553	Recovery of isoflavones from soy molasses	2000/07/04
6132795	Vegetable protein composition containing an isoflavone depleted vegetable protein material with an isoflavone containing material	2000/10/17
6495141	Recovery of isoflavones from soy molasses	2002/12/17
6521282	Aglucone isoflavone enriched vegetable flour and grit	2003/02/18
6544566	Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol	2003/04/08
6572876	Administering a composition containing plant sterol, soy protein and isoflavone for reducing LDL-cholesterol	2003/06/03
6579534	Composition containing soy hypocotyl material and plant sterol for reducing LDL-cholesterol	2003/06/17
6579561	Aglucone isoflavone enriched vegetable flour and vegetable grit and process for making the same from a vegetable material containing isoflavone	2003/06/17
6669952	Composition containing isoflavone material and plant sterol for reducing LDL-cholesterol	2003/12/30

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6497906	Dietary supplements comprising soy hypocotyls containing at least one isoflavone	2002/12/24
7312344	Dimeric isoflavones	2007/12/25
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Abbott Laboratories (3)

Number	Title	Issue Date
5985338	Plant protein for nutritional products and method of making same	1999/11/16
5804234	Plant protein for nutritional products and method of making same	1998/09/08
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Energetics (3)

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lycored bio (1)

Number	Title	Issue Date
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National Agriculture and Food Research Organization (1)

Number	Title	Issue Date
5776906	Method for promoting fat-degradation in fat cells	1998/07/07

purina animal nutrition (1)

Number	Title	Issue Date
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Regents of the University of California, The (1)

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DSM IP Assets B.V. (1)

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New York University Medical Center (1)

Number	Title	Issue Date
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HEALTH AND HUMAN SERVICES, DEPARTMENT OF, UNITED STATES OF AMERICA, THE (1)

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Wake Forest University (1)

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MARSHALL EDWARDS, INC. (1)

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MEIJI CO., LTD. (1)

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	439	Emerging	Average	Seminal	Medium High	Average	29.9
424	441	Emerging	Novel	Seminal	High	Average	38.4
514	25	Emerging	Average	Seminal	Medium	Average	26.0
514	27	Stable	Average	Seminal	Medium	Average	26.9
514	456	Emerging	Average	Seminal	Medium	Average	39.0
514	457	Stable	Average	Seminal	Medium	Average	36.5