Genistein for use in inhibiting osteroclasts

Overview

Information

Number: 5506211
Application: 08/241040
Filing date: 05/09/1994
Issue date: 04/09/1996
Inventor(s): Stephen Barnes, Harry C. Blair

US Classification: 424/439; 424/441; 514/25; 514/27; 514/456; 514/457

Citations

Yamanouchi Pharmaceutical Co. (2)

Number	Title	Issue Date
4841077	Isoflavone derivatives, and salts thereof, and cancerocidal and immunosuppressive agents containing the same	1989/06/20
4960908	Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents	1990/10/02

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. (2)

Number	Title	Issue Date
4826963	Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredient	1989/05/02
5043326	Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredients	1991/08/27

Chinoin Pharmaceutical and Chemical Works (1)

Number	Title	Issue Date
5110720	Dental composition and a process for the preparation thereof	1992/05/05

CHINOIN PHARMACEUTICAL AND CHEMICAL AND CO. (1)

Number	Title	Issue Date
5110720	Dental composition and a process for the preparation thereof	1992/05/05

ACDS Technologies, (1)

Number	Title	Issue Date
5424331	Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis	1995/06/13

Takeda Chemical Industries, (1)

Number	Title	Issue Date
4644012	Treatment for osteoporosis	1987/02/17

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt. (1)

Number	Title	Issue Date
4163746	Metabolic 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions containing the same	1979/08/07

Abstract

Abstract

Disclosed are methods and compositions for use in inhibiting osteoclast activity and, particularly, the osteoclast acid secretion that leads to bone-degradation. It is shown that the isoflavone genistein inhibits the acid secretion of osteoclasts and reduces bone resorption. The present invention thus provides advantageous methods for use in inhibiting osteoclast activity, as may be employed to reduce bone loss, for example, in patients with osteoporosis, metastatic bone cancers and renal failure.

Assignees with Similar Patents

Eli lilly and (16)

Number	Title
5792762	Dihydrobenzofluorene compounds, intermediates, compositions and methods
5821253	Tetrahydrobenzo
5834488	Dihydrobenzo
5843940	Benzothiophene compounds, compositions, and method
5843963	Benzothiophene compounds, intermediates, processes, compositions, and methods
5856341	Benzo
5889000	Naphthofluorene compounds, intermediates, compositions and methods
5952350	Naphthyl compounds and compositions, as estrogen receptor binding agents
5958917	Benzofluorene compounds, intermediates, compositions, and methods
5981570	Benzothiophene compounds, compositions, and methods
5985897	Benzothiphene compounds, intermediates, compositions, and methods
5998442	Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia
6121293	Benzothiophene compounds, compositions, and methods
6133288	Pentacyclic compounds, intermediates, processes, compositions, and methods
6133458	Benzo[B]indeno[2, 1-D]thiophene compounds, intermediates, compositions, and methods
6599920	Naphthalene compounds, intermediates, formulations, and methods

smithkline beecham (6)

Number	Title
6566373	Protease inhibitors
6458814	Vitronectin receptor antagonists
6534498	Protease inhibitors
6562842	Protease inhibitors
6583137	Protease inhibitors
6596715	Protease inhibitors

Board of Regents, the University of Texas System (5)

Number	Title
5534524	Suppression of bone resorption by quinolines
6060500	Suppression, by 5-lipoxygenase inhibitors, of bone resorption
6333313	Clinical use of oxytocin alone or in combination to treat bone disorders
6455541	Suppression, by 5-lipoxygenase inhibitors, of bone resorption
7468379	Inhibition of osteolytic lesions by SRC kinase inhibitors

Merck & co. (5)

Number	Title
5585388	Substituted pyridines useful as modulators of acetylcholine receptors
5663195	Method of preventing bone loss
5736560	Substituted pyridines useful as modulators of acetylcholine receptors
6008207	Anhydrous alendronate monosodium salt formulations
6376477	Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism

Bristol-Myers Squibb (5)

Number	Title
5280040	Methods for reducing bone loss using centchroman derivatives
5389646	Methods for treatment and prevention of bone loss using 2,3-benzopyrans
5464862	Method for inhibiting bone loss using centchroman derivatives
5698521	Native calcitonin mimetics
6395784	Benzamide ligands for the thyroid receptor

Referenced by

Archer-Daniels-Midland (18)

Number	Title	Issue Date
5702752	Production of isoflavone enriched fractions from soy protein extracts	1997/12/30
6680381	Recovery of isoflavones from soy molasses	2004/01/20
6706292	Recovery of isoflavones from soy molasses	2004/03/16
6900240	Method of preparing and using compositions extracted from vegetable matter for the treatment of cancer	2005/05/31
7285297	Method of reducing low density liproprotein cholesterol concentration	2007/10/23
6664382	Recovery of isoflavones from soy molasses	2003/12/16
5792503	Production of isoflavone enriched fractions from soy protein extracts	1998/08/11
6001368	Method for inhibiting or reducing the risk of macular degeneration	1999/12/14
6015785	Aglucone isofavone enriched vegetable protein extract and isolate and process for producing	2000/01/18
6083553	Recovery of isoflavones from soy molasses	2000/07/04
6132795	Vegetable protein composition containing an isoflavone depleted vegetable protein material with an isoflavone containing material	2000/10/17
6495141	Recovery of isoflavones from soy molasses	2002/12/17
6521282	Aglucone isoflavone enriched vegetable flour and grit	2003/02/18
6544566	Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol	2003/04/08
6572876	Administering a composition containing plant sterol, soy protein and isoflavone for reducing LDL-cholesterol	2003/06/03
6579534	Composition containing soy hypocotyl material and plant sterol for reducing LDL-cholesterol	2003/06/17
6579561	Aglucone isoflavone enriched vegetable flour and vegetable grit and process for making the same from a vegetable material containing isoflavone	2003/06/17
6669952	Composition containing isoflavone material and plant sterol for reducing LDL-cholesterol	2003/12/30

Novogen Research Pty. (9)

Number	Title	Issue Date
6599536	Therapy of estrogen-associated disorders	2003/07/29
6448237	Health supplements containing phyto-oestrogens, analogues or metabolites thereof	2002/09/10
7045155	Dietary supplements comprising soy hypocotyls containing at least one isoflavone	2006/05/16
6497906	Dietary supplements comprising soy hypocotyls containing at least one isoflavone	2002/12/24
7312344	Dimeric isoflavones	2007/12/25
7488494	Compositions and therapeutic methods involving isoflavones and analogues thereof	2009/02/10
6987098	Health supplement	2006/01/17
6562380	Methods for treating or reducing prediposition to breast cancer, pre-menstrual syndrome or symptoms associated with menopause by administration of phyto-estrogen	2003/05/13
6642212	Health supplements containing phyto-oestrogens, analogues or metabolites thereof	2003/11/04

Energetics (3)

Number	Title	Issue Date
6040333	Dietary supplements	2000/03/21
5807586	Method of dietary supplementation	1998/09/15
5654011	Dietary supplements	1997/08/05

Abbott Laboratories (3)

Number	Title	Issue Date
5985338	Plant protein for nutritional products and method of making same	1999/11/16
5804234	Plant protein for nutritional products and method of making same	1998/09/08
6440469	Plant protein for nutritional products and method of making same	2002/08/27

Takeda (2)

Number	Title	Issue Date
7638143	Process for preparing oral calcium compositions	2009/12/29
8007752	Process for preparing oral calcium compositions	2011/08/30

NA (2)

Number	Title	Issue Date
5932221	Genistin-enriched fraction from soy meal	1999/08/03
6482448	Soy formulations and their use for promoting health	2002/11/19

Novogen (2)

Number	Title	Issue Date
7033621	Isoflavone compositions produced from legumes	2006/04/25
6146668	Preparation of isoflavones from legumes	2000/11/14

Cargill (2)

Number	Title	Issue Date
6846506	Food product	2005/01/25
6589584	Food ingredient	2003/07/08

President And Fellows Of Harvard College (1)

Number	Title	Issue Date
7232897	Compositions and methods for modulating NH2-terminal Jun Kinase activity	2007/06/19

YAMAGUCHI, MASAYOSHI (1)

Number	Title	Issue Date
5935996	Composition for stimulating osteogenesis and preventingreduction of bone salt	1999/08/10

Institut National de la Recherche Agronomique (1)

Number	Title	Issue Date
8859612	Use of hesperidin or one of its derivatives for making a medicine for bone formation stimulation	2014/10/14

National Agriculture and Food Research Organization (1)

Number	Title	Issue Date
5776906	Method for promoting fat-degradation in fat cells	1998/07/07

CAGILL (1)

Number	Title	Issue Date
6733815	Food ingredient containing wheat gluten, soy grits and soy flour	2004/05/11

purina animal nutrition (1)

Number	Title	Issue Date
11576404	Isoflavone-supplemented milk replacers and systems and methods of feeding same to young animals	2023/02/14

DSM IP Assets B.V. (1)

Number	Title	Issue Date
11413263	Reducing the risk of pathological effects of traumatic brain injury	2022/08/16

HEALTH AND HUMAN SERVICES, DEPARTMENT OF, UNITED STATES OF AMERICA, THE (1)

Number	Title	Issue Date
6943191	Disubstituted lavendustin A analogs and pharmaceutical composition comprising the analogs	2005/09/13

MARSHALL EDWARDS, INC. (1)

Number	Title	Issue Date
7202273	Therapeutic methods and compositions involving isoflavones	2007/04/10

lycored bio (1)

Number	Title	Issue Date
6890561	Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants	2005/05/10

New York University Medical Center (1)

Number	Title	Issue Date
5824702	Genistein as a preventive against ultraviolet induced skin photodamage and cancer	1998/10/20

Wake Forest University (1)

Number	Title	Issue Date
6326366	Hormone replacement therapy	2001/12/04

Universitat Bern (1)

Number	Title	Issue Date
6638540	Plant extracts for the treatment of increased bone resorption	2003/10/28

MEIJI CO., LTD. (1)

Number	Title	Issue Date
6417224	Prophylactic, therapeutic agent for osteoporosis	2002/07/09

upfield us (1)

Number	Title	Issue Date
6787151	Composition for lowering blood cholesterol	2004/09/07

Regents of the University of California, The (1)

Number	Title	Issue Date
6812034	Fetuin-MGP-mineral complex in serum assayed to determine calcification risk	2004/11/02

Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	439	Emerging	Average	Seminal	Medium High	Average	29.9
424	441	Emerging	Novel	Seminal	High	Average	38.4
514	25	Emerging	Average	Seminal	Medium	Average	26.0
514	27	Stable	Average	Seminal	Medium	Average	26.9
514	456	Emerging	Average	Seminal	Medium	Average	39.0
514	457	Stable	Average	Seminal	Medium	Average	36.5