Collagen-based injectable drug delivery system and its use

Overview

Information

Number: 5807581
Application: 08/537073
Filing date: 09/29/1995
Issue date: 09/15/1998
Inventor(s): Joel S. Rosenblatt, Richard A. Berg

US Classification: 424/422; 424/424; 424/426; 424/484; 424/485; 424/486; 424/487; 604/890.1

Citations

Cellex Biosciences (3)

Number	Title	Issue Date
4863856	Weighted collagen microsponge for immobilizing bioactive materials	1989/09/05
4861714	Weighted collagen microsponge for immobilizing bioactive material	1989/08/29
4997753	Weighted collagen microsponge for immobilizing bioactive material	1991/03/05

University of Medicine and Dentistry of New Jersey (3)

Number	Title	Issue Date
4703108	Biodegradable matrix and methods for producing same	1987/10/27
4970298	Biodegradable matrix and methods for producing same	1990/11/13
4925924	Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof	1990/05/15

Cohesion Technologies (3)

Number	Title	Issue Date
4424208	Collagen implant material and method for augmenting soft tissue	1984/01/03
4488911	Non-antigenic collagen and articles of manufacture	1984/12/18
4689399	Collagen membranes for medical use	1987/08/25

ALLERGAN (2)

Number	Title	Issue Date
4582640	Injectable cross-linked collagen implant material	1986/04/15
4642117	Mechanically sheared collagen implant material and method	1987/02/10

COLLAGEN (1)

Number	Title	Issue Date
4557764	Process for preparing malleable collagen and the product thereof	1985/12/10

Research (1)

Number	Title	Issue Date
4179337	Non-immunogenic polypeptides	1979/12/18

Slovenska vedecko-technicka spolocnost, Dom techniky (1)

Number	Title	Issue Date
4165599	Arrangement for twisting of fibrous material	1979/08/28

Astra Lakemedel Aktiebolag (1)

Number	Title	Issue Date
4820857	.alpha.-bromodiethylcarbonate	1989/04/11

Atrix Laboratories (1)

Number	Title	Issue Date
4938763	Biodegradable in-situ forming implants and methods of producing the same	1990/07/03

Stanford University (1)

Number	Title	Issue Date
3949073	Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution	1976/04/06

ANGIODEVICE INTERNATIONAL (1)

Number	Title	Issue Date
5162430	Collagen-polymer conjugates	1992/11/10

VISION 2000 TECHNOLOGIES (1)

Number	Title	Issue Date
4164559	Collagen drug delivery device	1979/08/14

NATTERMANN & CIE (1)

Number	Title	Issue Date
4358442	Rosmarinic acid-phospholipide-complex	1982/11/09

Professional Dietetics S.r.l. (1)

Number	Title	Issue Date
5198465	Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen	1993/03/30

MDV Technologies (1)

Number	Title	Issue Date
5318780	Medical uses of in situ formed gels	1994/06/07

Abstract

Abstract

Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	422	Emerging	Average	Seminal	Medium	Average	54.3
424	424	Stable	Average	Average	Medium	Average	61.1
424	426	Emerging	Average	Seminal	Medium	Average	54.3
424	484	Emerging	Average	Seminal	Medium	Average	55.2
424	485	Stable	Sustaining	Seminal	Medium	Average	65.1
424	486	Emerging	Average	Seminal	Medium	Average	57.2
424	487	Stable	Average	Seminal	Medium	Average	53.7
604	890.1	Emerging	Average	Seminal	Medium High	Average	52.2