Bonding layers for medical device surface coatings

Overview

Information

Number: 5997517
Application: 08/791440
Filing date: 01/27/1997
Issue date: 12/07/1999
Inventor(s): Richard J. Whitbourne

US Classification: 424/422; 424/475; 424/482; 427/2.3; 604/12; 604/265; 623/901

Citations

Boston Scientific (5)

Number	Title	Issue Date
5452726	Intravascular guide wire and method for manufacture thereof	1995/09/26
4841976	Steerable catheter guide	1989/06/27
5443907	Coating for medical insertion guides	1995/08/22
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02
5047045	Multi-section coaxial angioplasty catheter	1991/09/10

Becton, Dickinson and (5)

Number	Title	Issue Date
4990357	Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings	1991/02/05
4589873	Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby	1986/05/20
4678660	Thermoplastic polyurethane anticoagulant alloy coating	1987/07/07
5084315	Lubricious coatings, medical articles containing same and method for their preparation	1992/01/28
5013717	Blood compatible, lubricious article and composition and method therefor	1991/05/07

Dentsply International (3)

Number	Title	Issue Date
4906237	Method of forming an improved hydrophilic coating on a polymer surface	1990/03/06
4459317	Process for the preparation of a hydrophilic coating	1984/07/10
4585666	Preparation of hydrophilic coating	1986/04/29

Hydromer (3)

Number	Title	Issue Date
4769013	Bio-effecting medical material and device	1988/09/06
4642267	Hydrophilic polymer blend	1987/02/10
4100309	Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same	1978/07/11

Cordis (3)

Number	Title	Issue Date
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20
4781703	Catheter assembly	1988/11/01

Terumo (2)

Number	Title	Issue Date
5670558	Medical instruments that exhibit surface lubricity when wetted	1997/09/23
4876126	Medical instrument and method for making	1989/10/24

Scimed Life Systems (2)

Number	Title	Issue Date
4841976	Steerable catheter guide	1989/06/27
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02

Angiotech International (2)

Number	Title	Issue Date
5331027	Lubricious hydrophilic coating, resistant to wet abrasion	1994/07/19
5525348	Coating compositions comprising pharmaceutical agents	1996/06/11

NA (2)

Number	Title	Issue Date
4330956	Dual coated wire trolling line	1982/05/25
4143423	Surgical lubricants	1979/03/13

Covidien (1)

Number	Title	Issue Date
4991602	Flexible guide wire with safety tip	1991/02/12

Unomedical A/S (1)

Number	Title	Issue Date
5416131	Article with a coating having friction-reducing properties in wet condition as well as a method for the production of such a coated article	1995/05/16

Medtronic (1)

Number	Title	Issue Date
5160790	Lubricious hydrogel coatings	1992/11/03

The United States of America as represented by the United States Energy (1)

Number	Title	Issue Date
3939049	Process for radiation grafting hydrogels onto organic polymeric substrates	1976/02/17

Cook (1)

Number	Title	Issue Date
5129890	Hydrophilically coated flexible wire guide	1992/07/14

UBE Industries, (1)

Number	Title	Issue Date
4872867	Compositions having antithrombogenic properties and blood contact medical devices using the same	1989/10/10

Superior Healthcare Group (1)

Number	Title	Issue Date
5061254	Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter	1991/10/29

Advanced cardiovascular Systems (1)

Number	Title	Issue Date
4867174	Guidewire for medical use	1989/09/19

Abbott Laboratories (1)

Number	Title	Issue Date
4534363	Coating for angiographic guidewire	1985/08/13

Ansell Healthcare Products (1)

Number	Title	Issue Date
5088125	Gloves	1992/02/18

Technicare (1)

Number	Title	Issue Date
4401124	Reflection enhancement of a biopsy needle	1983/08/30

Corning (1)

Number	Title	Issue Date
4087567	Anticoagulant coating method	1978/05/02

University of Utah (1)

Number	Title	Issue Date
4557724	Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters	1985/12/10

Eastman Chemical (1)

Number	Title	Issue Date
5523095	Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends	1996/06/04

Biocoat (1)

Number	Title	Issue Date
4959074	Method of hydrophilic coating of plastics	1990/09/25

STEWART, H. FRANKLIN (1)

Number	Title	Issue Date
5429839	Method for grafting preformed hydrophillic polymers onto hydrophobic polymer substrates	1995/07/04

Minnesota Mining and Manufacturing (1)

Number	Title	Issue Date
4977901	Article having non-crosslinked crystallized polymer coatings	1990/12/18

DOW CHEMICAL (1)

Number	Title	Issue Date
5620738	Non-reactive lubicious coating process	1997/04/15

Astra Meditec (1)

Number	Title	Issue Date
4373009	Method of forming a hydrophilic coating on a substrate	1983/02/08

Hoechst (1)

Number	Title	Issue Date
4758475	Isocyanate-free polyurethane dispersions	1988/07/19

Merit Medical Systems (1)

Number	Title	Issue Date
4950257	Catheter introducer with flexible tip	1990/08/21

Baxter International (1)

Number	Title	Issue Date
4835003	Medical tubing with water-activated lubricating coating	1989/05/30

Johnson & Johnson (1)

Number	Title	Issue Date
4381008	Methods of improving surface characteristics of extruded thermoplastic tubing and products produced thereby	1983/04/26

University of Medicine and Dentistry of New Jersey (1)

Number	Title	Issue Date
4879135	Drug bonded prosthesis and process for producing same	1989/11/07

CONGOLEUM (1)

Number	Title	Issue Date
4361626	Methods for bonding dissimilar synthetic polymeric materials and the products involved in and resulting from such methods	1982/11/30

Nec Tokin (1)

Number	Title	Issue Date
5069226	Catheter guidewire with pseudo elastic shape memory alloy	1991/12/03

High Voltage Engineering (1)

Number	Title	Issue Date
4055682	Catheter and the method of making	1977/10/25

LRC Products (1)

Number	Title	Issue Date
4482577	Coating process of elastomeric material	1984/11/13

stryker european operations (1)

Number	Title	Issue Date
4884579	Catheter guide wire	1989/12/05

Tyndale Plains-Hunter (1)

Number	Title	Issue Date
4729914	Hydrophilic coating and substrate coated therewith	1988/03/08

cardinal health switzerland 515 (1)

Number	Title	Issue Date
4883699	Polymeric article having high tensile energy to break when hydrated	1989/11/28

Abstract

Abstract

A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.

Assignees with Similar Patents

Boston Scientific (10)

Number	Title
6099563	Substrates, particularly medical devices, provided with bio-active/biocompatible coatings
6468649	Antimicrobial adhesion surface
101751019	Processes for producing polymer coatings through surface polymerization
101817980	Medical devices having coating with improved adhesion
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102316389	MEDICAL DEVICES HAVING FLUORINE-CONTAINING POLYMER COATINGS WITH IMPROVED ADHESION
7942926
7931932	Processes for producing polymer coatings through surface polymerization
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IPXMEDICAL, LLC (6)

Number	Title
7771468	Medicated stent having multi-layer polymer coating
7771468	Medicated stent having multi-layer polymer coating
8287590	Medicated stent having multi-layer polymer coating
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8101200	Targeted therapeutic agent release devices and methods of making and using the same

NA (6)

Number	Title
102423125	PHOTO-CURING OF THERMOPLASTIC COATINGS
102337031	Device Having a Hydrophilic Coating Comprising P-Toluene-Sulfonamide and a Method for the Preparation Thereof
102330765	COATINGS PREPARED FROM POLY(ETHYLENE OXIDE) AND PHOTO-INITATOR-CONTAINING SCAFFOLDS
102492914	FUNCTIONALIZED ADHESIVE MEDICAL GEL
102494919	Method of Preparing Polymeric Adhesive Compositions Utilizing the Mechanism of Ineraction Between the Polymer Components
102750423	Polymer-coated substrates for binding biomolecules and methods of making and using Thereof

Affinergy (5)

Number	Title
102288217	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
102292068	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
7972615	Peptide compositions for coating metal medical devices with vancomycin
102239549	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
102184332	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE

SURGICAL SPECIALTIES (4)

Number	Title
5997517	Bonding layers for medical device surface coatings
6110483	Adherent, flexible hydrogel and medicated coatings
6306176	Bonding layers for medical device surface coatings
6358557	Graft polymerization of substrate surfaces

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Number	Title	Issue Date
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8603634	End-capped poly(ester amide) copolymers	2013/12/10
8642062	Implantable device having a slow dissolving polymer	2014/02/04
8647655	Biocompatible polyacrylate compositions for medical applications	2014/02/11
8673334	Stent coatings comprising hydrophilic additives	2014/03/18
8685430	Tailored aliphatic polyesters for stent coatings	2014/04/01
8697110	Polymers comprising amorphous terpolymers and semicrystalline blocks	2014/04/15
8697113	Coating comprising a terpolymer comprising caprolactone and glycolide	2014/04/15
8703169	Implantable device having a coating comprising carrageenan and a biostable polymer	2014/04/22
8722826	Zwitterionic terpolymers, method of making and use on medical devices	2014/05/13
8778014	Coatings for preventing balloon damage to polymer coated stents	2014/07/15
8791171	Biodegradable coatings for implantable medical devices	2014/07/29
8808342	Nanoshell therapy	2014/08/19
8871236	Biocompatible polyacrylate compositions for medical applications	2014/10/28
8871883	Biocompatible coating for implantable medical devices	2014/10/28
8883175	Block copolymers of acrylates and methacrylates with fluoroalkenes	2014/11/11
8889170	Implantable device having a coating with a triblock copolymer	2014/11/18
8916188	Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block	2014/12/23
8932615	Implantable devices formed on non-fouling methacrylate or acrylate polymers	2015/01/13
8952123	Dioxanone-based copolymers for implantable devices	2015/02/10
8961584	Composite stent with regioselective material	2015/02/24
8986726	Biocompatible polyacrylate compositions for medical applications	2015/03/24
9056155	Coatings having an elastic primer layer	2015/06/16
9067000	End-capped poly(ester amide) copolymers	2015/06/30
9090745	Biodegradable triblock copolymers for implantable devices	2015/07/28
9101697	Hyaluronic acid based copolymers	2015/08/11
9339592	Polymers of fluorinated monomers and hydrocarbon monomers	2016/05/17
9345668	Implantable device having a slow dissolving polymer	2016/05/24
9364498	Heparin prodrugs and drug delivery stents formed therefrom	2016/06/14
9375445	Heparin prodrugs and drug delivery stents formed therefrom	2016/06/28
9381279	Implantable devices formed on non-fouling methacrylate or acrylate polymers	2016/07/05
9446173	Block copolymers of acrylates and methacrylates with fluoroalkenes	2016/09/20
9468706	Phosphoryl choline coating compositions	2016/10/18
9468707	Biodegradable triblock copolymers for implantable devices	2016/10/18
9580558	Polymers containing siloxane monomers	2017/02/28
9629944	Implantable device with a triblock polymer coating	2017/04/25
9737638	Polyester amide copolymers having free carboxylic acid pendant groups	2017/08/22
9814553	Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating	2017/11/14
10064982	PDLLA stent coating	2018/09/04
10076591	Absorbable coating for implantable device	2018/09/18
10155881	Substituted polycaprolactone for coating	2018/12/18

SurModics (26)

Number	Title	Issue Date
6214901	Bioactive agent release coating	2001/04/10
6344035	Bioactive agent release coating	2002/02/05
6890583	Bioactive agent release coating	2005/05/10
7008667	Bioactive agent release coating	2006/03/07
7056533	Medicament incorporation matrix	2006/06/06
7097850	Bioactive agent release coating and controlled humidity method	2006/08/29
7442402	Bioactive agent release coating	2008/10/28
7541048	Coating compositions for bioactive agents	2009/06/02
7544673	Coating compositions for bioactive agents	2009/06/09
7691476	Hydrophilic polymeric coatings for medical articles	2010/04/06
7794751	Medicament incorporation matrix	2010/09/14
7824704	Controlled release bioactive agent delivery device	2010/11/02
7833548	Bioactive agent release coating and controlled humidity method	2010/11/16
7976862	Controlled release bioactive agent delivery device	2011/07/12
8021680	Controlled release bioactive agent delivery device	2011/09/20
8034369	Controlled release bioactive agent delivery device	2011/10/11
8163327	Hydrophilic polymeric coatings for medical articles	2012/04/24
8246974	Medical devices and methods for producing the same	2012/08/21
9308355	Apparatus and methods for coating medical devices	2016/04/12
9623215	Apparatus and methods for coating medical devices	2017/04/18
9827401	Apparatus and methods for coating medical devices	2017/11/28
10099041	Apparatus and methods for coating medical devices	2018/10/16
10507309	Apparatus and methods for coating medical devices	2019/12/17
11628466	Apparatus and methods for coating medical devices	2023/04/18
11819590	Apparatus and methods for coating medical devices	2023/11/21
12496612	Coating application system and methods for coating rotatable medical devices	2025/12/16

Boston Scientific (17)

Number	Title	Issue Date
6638259	Biocompatible medical devices	2003/10/28
6663606	Biocompatible medical devices	2003/12/16
6908443	Intravascular guide wire and method for manufacture thereof	2005/06/21
7063674	Intravascular guide wire and method for manufacture thereof	2006/06/20
7214201	Intravascular guide wire and method for manufacture thereof	2007/05/08
7335264	Differentially coated medical devices, system for differentially coating medical devices, and coating method	2008/02/26
7674251	Medical devices including aerated adhesive bonds and methods of forming the same	2010/03/09
7951392	Microarray drug delivery coatings	2011/05/31
7955272	High performance coil wire	2011/06/07
8043278	Medical devices including aerated adhesive bonds and methods of forming the same	2011/10/25
8808272	Biocompatible medical devices	2014/08/19
11413170	Compositions, devices, kits and methods for attaching stent-containing medical devices to tissue	2022/08/16
11540857	Endovascular device with a tissue piercing distal probe and associated methods	2023/01/03
11992238	Endovascular device with a tissue piercing distal probe and associated methods	2024/05/28
12220334	Stent-containing medical devices and methods of using the same	2025/02/11
12533155	Endovascular device with a tissue piercing distal probe and associated methods	2026/01/27
12564404	Crossing occlusions in blood vessels	2026/03/03

C.R. Bard (16)

Number	Title	Issue Date
8070736	Waste management system	2011/12/06
8075539	Waste management system	2011/12/13
8597266	Waste management system	2013/12/03
8777912	Waste management system	2014/07/15
8926577	Waste management system	2015/01/06
9456920	Waste management system	2016/10/04
9463110	Waste management system	2016/10/11
9855163	Waste management system	2018/01/02
10660784	Waste management system	2020/05/26
10857324	Urinary catheter	2020/12/08
10874825	Urinary catheter	2020/12/29
11850370	Urinary catheter	2023/12/26
12589218	Intermittent-catheter assembly and methods thereof	2026/03/31
12611519	Intermittent-catheter assembly and methods thereof	2026/04/28
12691250	Intermittent-catheter assemblies and methods thereof	2026/07/28
12697467	Urinary catheter	2026/08/04

Abbott Laboratories (16)

Number	Title	Issue Date
7781551	Zwitterionic copolymers, method of making and use on medical devices	2010/08/24
7910678	Copolymers having 1-methyl-2-methoxyethyl moieties	2011/03/22
7928176	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2011/04/19
7928177	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/04/19
8048975	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/11/01
8063151	Methods for manufacturing copolymers having 1-methyl-2-methoxyethyl moieties and use of same	2011/11/22
8071705	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/12/06
8101156	Methods of manufacturing copolymers with zwitterionic moieties and dihydroxyphenyl moieties and use of same	2012/01/24
8202956	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2012/06/19
8399584	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2013/03/19
8465758	Drug delivery from stents	2013/06/18
8569435	Amino acid mimetic copolymers and medical devices coated with the copolymers	2013/10/29
8658749	Methods for manufacturing amino acid mimetic copolymers and use of same	2014/02/25
8753659	Drug delivery from stents	2014/06/17
8846839	Copolymers having zwitterionic moieties and dihdroxyphenyl moieties and medical devices coated with the copolymers	2014/09/30
9180225	Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties	2015/11/10

Innovatech, (16)

Number	Title	Issue Date
7147634	Electrosurgical electrode and method of manufacturing same	2006/12/12
7160297	Anti-microbial electrosurgical electrode and method of manufacturing the same	2007/01/09
7261925	Coating reinforcing underlayment and method of manufacturing same	2007/08/28
7288091	Anti-microbial electrosurgical electrode and method of manufacturing same	2007/10/30
7390326	Anti-microbial electrosurgical electrode and method of manufacturing same	2008/06/24
7618684	Method of forming a coating on a surface of a substrate	2009/11/17
7718212	Anti-microbial electrosurgical electrode and method of manufacturing same	2010/05/18
7838082	Method of forming a coating on a surface of a substrate	2010/11/23
7955637	Anti-microbial electrosurgical electrode and method of manufacturing same	2011/06/07
8814861	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814862	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814863	Electrosurgical electrode and method of manufacturing same	2014/08/26
8895133	Method of forming a coating on a surface of a substrate	2014/11/25
9630206	Electrosurgical electrode and method of manufacturing same	2017/04/25
10463420	Electrosurgical electrode and method of manufacturing same	2019/11/05
11246645	Electrosurgical electrode and method of manufacturing same	2022/02/15

Novartis (12)

Number	Title	Issue Date
8939577	Silicone hydrogel lenses with water-rich surfaces	2015/01/27
8944592	Silicone hydrogel lens with a crosslinked hydrophilic coating	2015/02/03
9005700	Method for making UV-absorbing ophthalmic lenses	2015/04/14
9239409	Silicone hydrogel lens with a crosslinked hydrophilic coating	2016/01/19
9244200	Silicone hydrogel lenses with water-rich surfaces	2016/01/26
9411171	Silicone hydrogel lenses with water-rich surfaces	2016/08/09
9507173	Silicone hydrogel lens with a crosslinked hydrophilic coating	2016/11/29
9708087	Silicone hydrogel lens with a crosslinked hydrophilic coating	2017/07/18
9738813	Silicone hydrogel lens with a crosslinked hydrophilic coating	2017/08/22
9816009	Silicone hydrogel lenses with water-rich surfaces	2017/11/14
10338408	Method for making improved UV-absorbing ophthalmic lenses	2019/07/02
10449740	Method for applying stable coating on silicone hydrogel contact lenses	2019/10/22

Cilag (8)

Number	Title	Issue Date
9034415	Surgical needle coatings and methods	2015/05/19
9221075	Surgical needle coatings and methods	2015/12/29
9259219	Surgical needle coatings and methods	2016/02/16
9266145	Surgical needle coatings and methods	2016/02/23
9332982	Surgical needle coatings and methods	2016/05/10
11197666	Surgical coated needles	2021/12/14
11717284	Surgical needle coatings and methods	2023/08/08
11832811	Surgical coated needles	2023/12/05

Alcon (7)

Number	Title	Issue Date
10781340	Silicone hydrogel lenses with water-rich surfaces	2020/09/22
10830923	Method for producing MPS-compatible water gradient contact lenses	2020/11/10
11001647	Soft silicone medical devices	2021/05/11
11002884	Method for applying stable coating on silicone hydrogel contact lenses	2021/05/11
11029446	Method for producing MPS-compatible water gradient contact lenses	2021/06/08
11029447	Method for producing MPS-compatible water gradient contact lenses	2021/06/08
11256003	Weekly and monthly disposable water gradient contact lenses	2022/02/22

Hollister (6)

Number	Title	Issue Date
8323255	Bowel management system	2012/12/04
8801683	Bowel management system	2014/08/12
10617789	Hydrophilic coatings and methods of forming the same	2020/04/14
11529439	Lubricious hydrophilic coatings and methods of forming the same	2022/12/20
11623020	Hydrophilic coatings and methods of forming the same	2023/04/11
12364789	Hydrophilic coatings and methods of forming the same	2025/07/22

IPXMEDICAL, LLC (6)

Number	Title	Issue Date
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8287590	Medicated stent having multi-layer polymer coating	2012/10/16
8287590	Medicated stent having multi-layer polymer coating	2012/10/16

BridgePoint Medical (5)

Number	Title	Issue Date
8202246	Crossing occlusions in blood vessels	2012/06/19
8337425	Endovascular device with a tissue piercing distal probe and associated methods	2012/12/25
9872685	Crossing occlusions in blood vessels	2018/01/23
10575869	Endovascular device with a tissue piercing distal probe and associated methods	2020/03/03
11065002	Crossing occlusions in blood vessels	2021/07/20

Yeda Research and Development Co. (4)

Number	Title	Issue Date
10940111	Surface treatment by water-soluble polymers and lipids/liposomes	2021/03/09
11633358	Surface treatment by water-soluble polymers and lipids/liposomes	2023/04/25
11883533	Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes	2024/01/30
12274786	Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes	2025/04/15

Biocompatibles UK (3)

Number	Title	Issue Date
7306625	Balloon expandable stent	2007/12/11
7794775	Balloon expandable stent	2010/09/14
8052746	Balloon expandable stent	2011/11/08

Angiotech International (3)

Number	Title	Issue Date
8313760	Compositions and methods for coating medical implants	2012/11/20
8372420	Compositions and methods for coating medical implants	2013/02/12
8425927	Compositions and methods for coating medical implants	2013/04/23

Medtronic (3)

Number	Title	Issue Date
6273878	Shaft for medical catheters	2001/08/14
6756449	AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods	2004/06/29
7064168	A.sub.nB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods	2006/06/20

Ethicon (3)

Number	Title	Issue Date
7041088	Medical devices having durable and lubricious polymeric coating	2006/05/09
10004494	Surgical needle coatings and methods	2018/06/26
10939907	Surgical needle coatings and methods	2021/03/09

Innovative Surface Technologies (3)

Number	Title	Issue Date
9539371	Coating agents and coated articles	2017/01/10
10266620	Coating agents and coated articles	2019/04/23
10744233	Crystallization inhibitor compositions for implantable urological devices	2020/08/18

Johnson & Johnson (2)

Number	Title	Issue Date
6500481	Biomedical devices with amid-containing coatings	2002/12/31
6838491	Biomedical devices with hydrophilic coatings	2005/01/04

ZB MANUFACTURING, LLC (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

Biomet (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

Scimed Life Systems (2)

Number	Title	Issue Date
7470239	High performance coil wire	2008/12/30
7946999	High performance coil wire	2011/05/24

Biomet Manufacturing (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

SICPA (1)

Number	Title	Issue Date
10711168	Process for assembling elements containing biological substances	2020/07/14

Keimar (1)

Number	Title	Issue Date
7630747	Apparatus for ascertaining blood characteristics and probe for use therewith	2009/12/08

Abbott Cardiocascular Systems (1)

Number	Title	Issue Date
8758801	Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages	2014/06/24

advanced cardiocasvular systems (1)

Number	Title	Issue Date
7967998	Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability	2011/06/28

Ecolab (1)

Number	Title	Issue Date
6591970	Water-activatable conveyor lubricant and method for transporting articles on a conveyor system	2003/07/15

Endovascular Devices (1)

Number	Title	Issue Date
7396538	Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device	2008/07/08

Zimmer (1)

Number	Title	Issue Date
6183516	Method for improved bonding of prosthetic devices to bone	2001/02/06

Terumo (1)

Number	Title	Issue Date
11872326	Medical instrument	2024/01/16

COOK MEDICAL TECHNOLOGIES (1)

Number	Title	Issue Date
7914841	Inline application of coatings	2011/03/29

abbott cardiovasular systems (1)

Number	Title	Issue Date
8109904	Drug delivery medical devices	2012/02/07

Shimadzu (1)

Number	Title	Issue Date
7175812	Automatic sampler and needle for the same	2007/02/13

MicroVention (1)

Number	Title	Issue Date
10350094	Implantable device with adhesive properties	2019/07/16

United Technologies (1)

Number	Title	Issue Date
10309018	Composite article having layer with co-continuous material regions	2019/06/04

Mitsubishi Polyester Film (1)

Number	Title	Issue Date
7384684	Polyester film with hydrophilic coating, process for its production and its use	2008/06/10

FujiFilm (1)

Number	Title	Issue Date
11351761	Composition for laminated material used for medical lubricating member, laminated material used for medical lubricating member, medical lubricating member, and medical device	2022/06/07

SURGICAL SPECIALTIES (1)

Number	Title	Issue Date
6306176	Bonding layers for medical device surface coatings	2001/10/23

cardinal health switzerland 515 (1)

Number	Title	Issue Date
8133346	Medical device having bonding regions and method of making the same	2012/03/13

Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	422	Emerging	Sustaining	Seminal	Medium	Average	52.2
424	475	Declining	Sustaining	Seminal	Medium	Average	64.7
424	482	Stable	Sustaining	Seminal	Medium	Average	68.9
427	2.3	Stable	Sustaining	Seminal	Medium	Average	68.3
604	12	Stable	Sustaining	Seminal	Medium	Average	56.5
604	265	Emerging	Average	Seminal	Medium	Average	60.6
623	901	Stable	Sustaining	Seminal	Medium	Average	65.3