System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry
Overview
Citations
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1989/04/11 |
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Apparatus and methods of use in the mass analysis of chemical samples |
1990/03/13 |
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Method of preparing a sample for analysis by laser desorption ionization mass spectrometry |
1997/07/01 |
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Abstract
Abstract
The invention relates to a system and method for on-line coupling of liquid capillary separation with matrix-assisted laser desorption ionization mass spectrometric analysis. In this system and method, analyte from liquid capillary separation is mixed with matrix molecules for matrix-assisted laser desorption ionization. Continuous flow of the analyte/matrix combined with vacuum conditions allows evaporation and crystallization of homogeneous samples on a solid sample surface. Dual use of laser irradiation to desorb/ionize and remove excess sample facilitates on-line use and automation.
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Tech Analysis
| Class |
Subclass |
Type |
Reference Factor |
Citation Factor |
Strength |
Grant time |
Early grant (%) |
|
250
|
288
|
Emerging |
Average |
Seminal |
Medium High |
Average |
54.2 |