Methods for microsphere production
Overview
Citations
- California institute of Technology (2)
-
| Number |
Title |
Issue Date |
| 4138383 |
Preparation of small bio-compatible microspheres |
1979/02/06 |
| 4981625 |
Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
1991/01/01 |
- Vanderbilt University (1)
-
| Number |
Title |
Issue Date |
| 5260002 |
Method and apparatus for producing uniform polymeric spheres |
1993/11/09 |
- Suzuki Yushi Industrial Co. (1)
-
| Number |
Title |
Issue Date |
| 5376347 |
Uniform inorganic micropheres and production thereof |
1994/12/27 |
- P. H. Glatfelter (1)
-
| Number |
Title |
Issue Date |
| 5643506 |
Continuous production of Emulsions and microcapsules of uniform particle size |
1997/07/01 |
- LI, KAI (1)
-
| Number |
Title |
Issue Date |
| 5599889 |
Method of forming polymer microspheres |
1997/02/04 |
- Connaught Laboratories (1)
-
| Number |
Title |
Issue Date |
| 4956128 |
Droplet generation |
1990/09/11 |
- Liquid Gas Co. (1)
-
| Number |
Title |
Issue Date |
| 5376347 |
Uniform inorganic micropheres and production thereof |
1994/12/27 |
- Mitsubishi Pharma (1)
-
| Number |
Title |
Issue Date |
| 5656299 |
Sustained release microsphere preparation containing antipsychotic drug and production process thereof |
1997/08/12 |
- LI, WEN HUI (1)
-
| Number |
Title |
Issue Date |
| 5599889 |
Method of forming polymer microspheres |
1997/02/04 |
- DIAMOND TECHNOLOGY PARTNERSHIP (1)
-
| Number |
Title |
Issue Date |
| 4444961 |
Process and apparatus for preparing uniform size polymer beads |
1984/04/24 |
- Osaka Gas (1)
-
| Number |
Title |
Issue Date |
| 5376347 |
Uniform inorganic micropheres and production thereof |
1994/12/27 |
- Fujimoro Kogyo Co. (1)
-
| Number |
Title |
Issue Date |
| 5635574 |
Microsphere and method for production thereof |
1997/06/03 |
- STOVER, HARALD D.H. (1)
-
| Number |
Title |
Issue Date |
| 5599889 |
Method of forming polymer microspheres |
1997/02/04 |
Abstract
Abstract
A process for forming microspheres that includes passing a first composition containing polymer and solvent through an orifice and directly into a second composition containing water and a microsphere-stabilizing agent, under at least one of conditions (a) and (b), wherein (a) the first composition flows through a first conduit along a first path and exits the first conduit at the orifice, the second composition flows through a second conduit along a second path in an upstream to downstream direction, the first conduit is connected to the second conduit and terminates at the orifice, the first and second paths being orientated at an angle .theta. relative to each other, wherein 0.degree.<.theta.<180.degree.; (b) the first composition being at a first temperature and including a solvent having a boiling point, the second composition being at a second temperature, the boiling point of the solvent being less than the second temperature; and forming a composition including water and microspheres, the microspheres being formed, at least in part, by the polymer. Such microspheres are suitable for use in the delivery of bioactive agents for animal, aquarian and human use, as a means of radio-imaging tissue, as well as for the controlled release of agro-chemicals.
Assignees with Similar Patents
Referenced by
- Boston Scientific (35)
-
| Number |
Title |
Issue Date |
| 7053134 |
Forming a chemically cross-linked particle of a desired shape and diameter |
2006/05/30 |
| 7094369 |
Processes for manufacturing polymeric microspheres |
2006/08/22 |
| 7131997 |
Tissue treatment |
2006/11/07 |
| 7311861 |
Embolization |
2007/12/25 |
| 7449236 |
Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
2008/11/11 |
| 7462366 |
Drug delivery particle |
2008/12/09 |
| 7501179 |
Block copolymer particles |
2009/03/10 |
| 7507772 |
Forming a chemically cross-linked particle of a desired shape and diameter |
2009/03/24 |
| 7588780 |
Embolization |
2009/09/15 |
| 7588825 |
Embolic compositions |
2009/09/15 |
| 7611542 |
Tissue treatment |
2009/11/03 |
| 7666333 |
Embolization |
2010/02/23 |
| 7727555 |
Particles |
2010/06/01 |
| 7736671 |
Embolization |
2010/06/15 |
| 7842377 |
Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
2010/11/30 |
| 7858183 |
Particles |
2010/12/28 |
| 7883490 |
Mixing and delivery of therapeutic compositions |
2011/02/08 |
| 7947368 |
Block copolymer particles |
2011/05/24 |
| 7951402 |
Drug delivery particle |
2011/05/31 |
| 7963287 |
Tissue-treatment methods |
2011/06/21 |
| 7964123 |
Embolization |
2011/06/21 |
| 7976823 |
Ferromagnetic particles and methods |
2011/07/12 |
| 8012454 |
Embolization |
2011/09/06 |
| 8152839 |
Embolic coils |
2012/04/10 |
| 8173176 |
Embolization |
2012/05/08 |
| 8216612 |
Embolization |
2012/07/10 |
| 8273324 |
Embolization |
2012/09/25 |
| 8394400 |
Bulking agent |
2013/03/12 |
| 8414927 |
Cross-linked polymer particles |
2013/04/09 |
| 8425550 |
Embolic coils |
2013/04/23 |
| 8430105 |
Tissue-treatment methods |
2013/04/30 |
| 8586071 |
Bulking agents |
2013/11/19 |
| 9283035 |
Tissue-treatment methods |
2016/03/15 |
| 9463426 |
Methods and systems for coating particles |
2016/10/11 |
| 10398724 |
Bulking agents |
2019/09/03 |
- Ecole Polytechnique Federale de Lausanne (18)
-
| Number |
Title |
Issue Date |
| 7592009 |
Polypeptide ligands for targeting cartilage and methods of use thereof |
2009/09/22 |
| 9517257 |
Erythrocyte-binding therapeutics |
2016/12/13 |
| 9518087 |
Erythrocyte-binding therapeutics |
2016/12/13 |
| 9540428 |
Extracellular matrix heparin-binding domains |
2017/01/10 |
| 9814780 |
Compositions for inducing antigen-specific tolerance |
2017/11/14 |
| 9850296 |
Erythrocyte-binding therapeutics |
2017/12/26 |
| 9878048 |
Compositions for generating immune tolerance by targeting erythrocytes |
2018/01/30 |
| 9879062 |
Protein-binding peptide isolated from placenta growth factor |
2018/01/30 |
| 9901645 |
Methods for reducing immune responses |
2018/02/27 |
| 9901646 |
Methods for induction of antigen-specific immune tolerance |
2018/02/27 |
| 10821157 |
Glycotargeting therapeutics |
2020/11/03 |
| 10946079 |
Glycotargeting therapeutics |
2021/03/16 |
| 11654188 |
Glycotargeting therapeutics |
2023/05/23 |
| 11666638 |
Glycotargeting therapeutics |
2023/06/06 |
| 11793882 |
Glycotargeting therapeutics |
2023/10/24 |
| 11801305 |
Glycotargeting therapeutics |
2023/10/31 |
| 11884721 |
Erythrocyte-binding therapeutics |
2024/01/30 |
| 12060414 |
Erythrocyte-binding therapeutics |
2024/08/13 |
- École polytechnique fédérale de lausanne (9)
-
| Number |
Title |
Issue Date |
| 10046056 |
Glycotargeting therapeutics |
2018/08/14 |
| 10265415 |
Compositions for inducing antigen-specific tolerance |
2019/04/23 |
| 10392437 |
Erythrocyte-binding therapeutics |
2019/08/27 |
| 10471155 |
Antigen-specific tolerance and compositions for induction of same |
2019/11/12 |
| 10800838 |
Erythrocyte-binding therapeutics |
2020/10/13 |
| 10919963 |
Erythrocyte-binding therapeutics |
2021/02/16 |
| 10940209 |
Glycotargeting therapeutics |
2021/03/09 |
| 10953101 |
Glycotargeting therapeutics |
2021/03/23 |
| 11246943 |
Antigen-specific tolerance and compositions for induction of same |
2022/02/15 |
- Board of Trustees of the University of Illinois, The (5)
-
| Number |
Title |
Issue Date |
| 6669961 |
Microparticles |
2003/12/30 |
| 7309500 |
Microparticles |
2007/12/18 |
| 7368130 |
Microparticles |
2008/05/06 |
| 7748343 |
Electrohydrodynamic spraying system |
2010/07/06 |
| 8409621 |
Microparticles |
2013/04/02 |
- anokion (5)
-
| Number |
Title |
Issue Date |
| 11253579 |
Compositions and methods for inducing immune tolerance |
2022/02/22 |
| 12383617 |
Compositions and methods concerning immune tolerance |
2025/08/12 |
| 10821157 |
Glycotargeting therapeutics |
2020/11/03 |
| 11654188 |
Glycotargeting therapeutics |
2023/05/23 |
| 11666638 |
Glycotargeting therapeutics |
2023/06/06 |
- Abbott Cardiovascular Systems (5)
-
| Number |
Title |
Issue Date |
| 8323676 |
Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug |
2012/12/04 |
| 8765162 |
Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same |
2014/07/01 |
| 8911766 |
Drug delivery compositions including nanoshells for triggered drug release |
2014/12/16 |
| 8916187 |
Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same |
2014/12/23 |
| 9295663 |
Drug coated balloon with in-situ formed drug containing microspheres |
2016/03/29 |
- Biosphere Medical, (5)
-
| Number |
Title |
Issue Date |
| 8226926 |
Compositions and methods using microspheres and non-ionic contrast agents |
2012/07/24 |
| 8709384 |
Compositions and methods using microspheres and non-ionic contrast agents |
2014/04/29 |
| 8741351 |
Microspheres for active embolization |
2014/06/03 |
| 9040022 |
Compositions and methods using microspheres and non-ionic contrast agents |
2015/05/26 |
| 10265271 |
Microspheres for the treatment of a prostate hyperplasia by active embolization |
2019/04/23 |
- Vascular Therapies, (4)
-
| Number |
Title |
Issue Date |
| 6726923 |
Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts |
2004/04/27 |
| 7807191 |
Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts |
2010/10/05 |
| 8858982 |
Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts |
2014/10/14 |
| 10272073 |
Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts |
2019/04/30 |
- Novo Nordisk A/S (4)
-
| Number |
Title |
Issue Date |
| 7666844 |
Dry mouldable drug formulation |
2010/02/23 |
| 8084053 |
Dry mouldable drug formulation |
2011/12/27 |
| 8454997 |
Solid dose micro implant |
2013/06/04 |
| 8518430 |
Dry mouldable drug formulation |
2013/08/27 |
- University of Utah (3)
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| Number |
Title |
Issue Date |
| 8685432 |
Controlled release tissue graft combination biomaterials |
2014/04/01 |
| 9889235 |
Implantable devices for bone or joint defects |
2018/02/13 |
| 10207030 |
Implantable devices for bone or joint defects |
2019/02/19 |
- Chitogenics (3)
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| Number |
Title |
Issue Date |
| 6809085 |
Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use |
2004/10/26 |
| 6894035 |
Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
2005/05/17 |
| 7238678 |
Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
2007/07/03 |
- Alkermes (2)
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| Number |
Title |
Issue Date |
| 7118763 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
2006/10/10 |
| 7547452 |
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
2009/06/16 |
- Solubest (2)
-
| Number |
Title |
Issue Date |
| 6878693 |
Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
2005/04/12 |
| 7081450 |
Water soluble nanoparticles of hydrophilic and hydrophobic active materials and an apparatus and method for their production |
2006/07/25 |
- Scimed Life Systems (2)
-
| Number |
Title |
Issue Date |
| 7288319 |
Forming a chemically cross-linked particle of a desired shape and diameter |
2007/10/30 |
| 8007509 |
Coil assemblies, components and methods |
2011/08/30 |
- University of Chicago (2)
-
| Number |
Title |
Issue Date |
| 11253579 |
Compositions and methods for inducing immune tolerance |
2022/02/22 |
| 12383617 |
Compositions and methods concerning immune tolerance |
2025/08/12 |
- Hydromer (1)
-
| Number |
Title |
Issue Date |
| 7008979 |
Coating composition for multiple hydrophilic applications |
2006/03/07 |
- HELLEBORE, LLC. (1)
-
| Number |
Title |
Issue Date |
| 9988517 |
Physical colorants for plastics based on the Christiansen effect |
2018/06/05 |
- Empire Technology Development (1)
-
| Number |
Title |
Issue Date |
| 9988517 |
Physical colorants for plastics based on the Christiansen effect |
2018/06/05 |
- Asahi Glass (1)
-
| Number |
Title |
Issue Date |
| 7022300 |
Process for producing inorganic spheres |
2006/04/04 |
- Celgene (1)
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| Number |
Title |
Issue Date |
| 8137684 |
Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
2012/03/20 |
- STERN, MOSHE (1)
-
| Number |
Title |
Issue Date |
| 8167122 |
Apparatus and cartridge for storage of compressed hydrogen gas |
2012/05/01 |
- MicroFab Technologies (1)
-
| Number |
Title |
Issue Date |
| 6998074 |
Method for forming polymer microspheres |
2006/02/14 |
- TAIWAN BIOTECH CO. (1)
-
| Number |
Title |
Issue Date |
| 8641900 |
Method and device for continuously preparing microspheres, and collection unit thereof |
2014/02/04 |
- Merit Medical Systems (1)
-
| Number |
Title |
Issue Date |
| 10293063 |
Compositions and methods using microspheres and non-ionic contrast agents |
2019/05/21 |
- immusoft (1)
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| Number |
Title |
Issue Date |
| 11103582 |
Method to achieve extended expression of DNA infused into liver |
2021/08/31 |
- C. EN. (1)
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| Number |
Title |
Issue Date |
| 8167122 |
Apparatus and cartridge for storage of compressed hydrogen gas |
2012/05/01 |
- École polytechnique fédérale de lausanna (1)
-
| Number |
Title |
Issue Date |
| 10265416 |
Compositions for generation of immune tolerance to specific antigens |
2019/04/23 |
- NA (1)
-
| Number |
Title |
Issue Date |
| 7008643 |
Delivery system for biological material |
2006/03/07 |
- Oakwood Laboratories L.L.C. (1)
-
| Number |
Title |
Issue Date |
| 11623190 |
System and method for making microspheres and emulsions |
2023/04/11 |
- abott cardiovascular systems (1)
-
| Number |
Title |
Issue Date |
| 9439869 |
Nanoshells on polymers |
2016/09/13 |
- stryker european operations (1)
-
| Number |
Title |
Issue Date |
| 8101197 |
Forming coils |
2012/01/24 |
- EVONIK CORPORATION (1)
-
| Number |
Title |
Issue Date |
| 9399019 |
Polymorph compositions, methods of making, and uses thereof |
2016/07/26 |
Tech Analysis
| Class |
Subclass |
Type |
Reference Factor |
Citation Factor |
Strength |
Grant time |
Early grant (%) |
|
264
|
4.1
|
Emerging |
Average |
Seminal |
Medium |
Average |
27.9 |
|
264
|
4.3
|
Declining |
Average |
Average |
Medium |
Average |
33.5 |
|
264
|
4.33
|
Stable |
Average |
Seminal |
Medium |
Average |
39.0 |
|
264
|
4.6
|
Declining |
Average |
Average |
Medium |
Average |
33.3 |
|
427
|
213.3
|
Stable |
Average |
Seminal |
Medium High |
Average |
36.6 |
|
427
|
213.31
|
Stable |
Average |
Seminal |
Medium |
Average |
32.0 |
|
427
|
213.35
|
Declining |
Average |
Average |
Medium |
Average |
26.9 |
|
427
|
213.36
|
Declining |
Average |
Average |
Medium |
Average |
37.9 |
|
428
|
402.2
|
Stable |
Average |
Average |
Medium |
Average |
34.8 |
|
428
|
402.21
|
Stable |
Average |
Average |
Medium |
Average |
41.7 |