Bonding layers for medical device surface coatings

Overview

Information

Number: 6306176
Application: 09/400867
Filing date: 09/21/1999
Issue date: 10/23/2001
Inventor(s): Richard J. Whitbourne

US Classification: 427/2.24; 523/113; 623/1.46; 623/23.59

Citations

Becton, Dickinson and (5)

Number	Title	Issue Date
4589873	Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby	1986/05/20
4678660	Thermoplastic polyurethane anticoagulant alloy coating	1987/07/07
4990357	Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings	1991/02/05
5084315	Lubricious coatings, medical articles containing same and method for their preparation	1992/01/28
5013717	Blood compatible, lubricious article and composition and method therefor	1991/05/07

Hydromer (5)

Number	Title	Issue Date
4847324	Hydrophilic polyvinylbutyral alloys	1989/07/11
4100309	Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same	1978/07/11
4119094	Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same	1978/10/10
4769013	Bio-effecting medical material and device	1988/09/06
4642267	Hydrophilic polymer blend	1987/02/10

Boston Scientific (4)

Number	Title	Issue Date
5452726	Intravascular guide wire and method for manufacture thereof	1995/09/26
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02
5443907	Coating for medical insertion guides	1995/08/22
5047045	Multi-section coaxial angioplasty catheter	1991/09/10

Dentsply International (3)

Number	Title	Issue Date
4906237	Method of forming an improved hydrophilic coating on a polymer surface	1990/03/06
4585666	Preparation of hydrophilic coating	1986/04/29
4459317	Process for the preparation of a hydrophilic coating	1984/07/10

Cordis (3)

Number	Title	Issue Date
4781703	Catheter assembly	1988/11/01
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20

Medtronic (2)

Number	Title	Issue Date
5824048	Method for delivering a therapeutic substance to a body lumen	1998/10/20
5160790	Lubricious hydrogel coatings	1992/11/03

Angiotech International (2)

Number	Title	Issue Date
5525348	Coating compositions comprising pharmaceutical agents	1996/06/11
5331027	Lubricious hydrophilic coating, resistant to wet abrasion	1994/07/19

NA (2)

Number	Title	Issue Date
4143423	Surgical lubricants	1979/03/13
4330956	Dual coated wire trolling line	1982/05/25

Baxter International (2)

Number	Title	Issue Date
4835003	Medical tubing with water-activated lubricating coating	1989/05/30
4459318	Method for forming a self-lubricating fill tube	1984/07/10

Terumo (2)

Number	Title	Issue Date
4876126	Medical instrument and method for making	1989/10/24
5670558	Medical instruments that exhibit surface lubricity when wetted	1997/09/23

Advanced cardiovascular Systems (1)

Number	Title	Issue Date
4867174	Guidewire for medical use	1989/09/19

Scimed Life Systems (1)

Number	Title	Issue Date
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02

Minnesota Mining and Manufacturing (1)

Number	Title	Issue Date
4977901	Article having non-crosslinked crystallized polymer coatings	1990/12/18

Hoechst (1)

Number	Title	Issue Date
4758475	Isocyanate-free polyurethane dispersions	1988/07/19

LRC Products (1)

Number	Title	Issue Date
4482577	Coating process of elastomeric material	1984/11/13

Johnson & Johnson (1)

Number	Title	Issue Date
4381008	Methods of improving surface characteristics of extruded thermoplastic tubing and products produced thereby	1983/04/26

Astra Meditec (1)

Number	Title	Issue Date
4373009	Method of forming a hydrophilic coating on a substrate	1983/02/08

Covidien (1)

Number	Title	Issue Date
4991602	Flexible guide wire with safety tip	1991/02/12

STEWART, H. FRANKLIN (1)

Number	Title	Issue Date
5429839	Method for grafting preformed hydrophillic polymers onto hydrophobic polymer substrates	1995/07/04

Corning (1)

Number	Title	Issue Date
4087567	Anticoagulant coating method	1978/05/02

University of Utah (1)

Number	Title	Issue Date
4557724	Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters	1985/12/10

Baylor College Of Medicine (1)

Number	Title	Issue Date
5853745	Medical implant having a durable, resilient and effective antimicrobial coating	1998/12/29

Abbott Laboratories (1)

Number	Title	Issue Date
4534363	Coating for angiographic guidewire	1985/08/13

Technicare (1)

Number	Title	Issue Date
4401124	Reflection enhancement of a biopsy needle	1983/08/30

stryker european operations (1)

Number	Title	Issue Date
4884579	Catheter guide wire	1989/12/05

Cook (1)

Number	Title	Issue Date
5129890	Hydrophilically coated flexible wire guide	1992/07/14

University of Medicine and Dentistry of New Jersey (1)

Number	Title	Issue Date
4879135	Drug bonded prosthesis and process for producing same	1989/11/07

SURGICAL SPECIALTIES (1)

Number	Title	Issue Date
5997517	Bonding layers for medical device surface coatings	1999/12/07

Merit Medical Systems (1)

Number	Title	Issue Date
4950257	Catheter introducer with flexible tip	1990/08/21

The United States of America as represented by the United States Energy (1)

Number	Title	Issue Date
3939049	Process for radiation grafting hydrogels onto organic polymeric substrates	1976/02/17

UBE Industries, (1)

Number	Title	Issue Date
4872867	Compositions having antithrombogenic properties and blood contact medical devices using the same	1989/10/10

High Voltage Engineering (1)

Number	Title	Issue Date
4055682	Catheter and the method of making	1977/10/25

Nec Tokin (1)

Number	Title	Issue Date
5069226	Catheter guidewire with pseudo elastic shape memory alloy	1991/12/03

Unomedical A/S (1)

Number	Title	Issue Date
5416131	Article with a coating having friction-reducing properties in wet condition as well as a method for the production of such a coated article	1995/05/16

CONGOLEUM (1)

Number	Title	Issue Date
4361626	Methods for bonding dissimilar synthetic polymeric materials and the products involved in and resulting from such methods	1982/11/30

cardinal health switzerland 515 (1)

Number	Title	Issue Date
4883699	Polymeric article having high tensile energy to break when hydrated	1989/11/28

Tyndale Plains-Hunter (1)

Number	Title	Issue Date
4729914	Hydrophilic coating and substrate coated therewith	1988/03/08

Superior Healthcare Group (1)

Number	Title	Issue Date
5061254	Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter	1991/10/29

Eastman Chemical (1)

Number	Title	Issue Date
5523095	Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends	1996/06/04

Ansell Healthcare Products (1)

Number	Title	Issue Date
5088125	Gloves	1992/02/18

Biocoat (1)

Number	Title	Issue Date
4959074	Method of hydrophilic coating of plastics	1990/09/25

C.R. Bard (1)

Number	Title	Issue Date
4773901	Catheter with selectively rigidified portion	1988/09/27

Abstract

Abstract

The medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers containing hydroxyl, amine, carboxyl, amide or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.

Assignees with Similar Patents

Referenced by

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Number	Title	Issue Date
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Abbott Laboratories (17)

Number	Title	Issue Date
7781551	Zwitterionic copolymers, method of making and use on medical devices	2010/08/24
7910678	Copolymers having 1-methyl-2-methoxyethyl moieties	2011/03/22
7928176	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2011/04/19
7928177	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/04/19
8048975	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/11/01
8063151	Methods for manufacturing copolymers having 1-methyl-2-methoxyethyl moieties and use of same	2011/11/22
8071705	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/12/06
8101156	Methods of manufacturing copolymers with zwitterionic moieties and dihydroxyphenyl moieties and use of same	2012/01/24
8202956	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2012/06/19
8361538	Methods for applying an application material to an implantable device	2013/01/29
8399584	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2013/03/19
8465758	Drug delivery from stents	2013/06/18
8569435	Amino acid mimetic copolymers and medical devices coated with the copolymers	2013/10/29
8658749	Methods for manufacturing amino acid mimetic copolymers and use of same	2014/02/25
8753659	Drug delivery from stents	2014/06/17
8846839	Copolymers having zwitterionic moieties and dihdroxyphenyl moieties and medical devices coated with the copolymers	2014/09/30
9180225	Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties	2015/11/10

Innovatech, (16)

Number	Title	Issue Date
7147634	Electrosurgical electrode and method of manufacturing same	2006/12/12
7160297	Anti-microbial electrosurgical electrode and method of manufacturing the same	2007/01/09
7261925	Coating reinforcing underlayment and method of manufacturing same	2007/08/28
7288091	Anti-microbial electrosurgical electrode and method of manufacturing same	2007/10/30
7390326	Anti-microbial electrosurgical electrode and method of manufacturing same	2008/06/24
7618684	Method of forming a coating on a surface of a substrate	2009/11/17
7718212	Anti-microbial electrosurgical electrode and method of manufacturing same	2010/05/18
7838082	Method of forming a coating on a surface of a substrate	2010/11/23
7955637	Anti-microbial electrosurgical electrode and method of manufacturing same	2011/06/07
8814861	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814862	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814863	Electrosurgical electrode and method of manufacturing same	2014/08/26
8895133	Method of forming a coating on a surface of a substrate	2014/11/25
9630206	Electrosurgical electrode and method of manufacturing same	2017/04/25
10463420	Electrosurgical electrode and method of manufacturing same	2019/11/05
11246645	Electrosurgical electrode and method of manufacturing same	2022/02/15

Cilag (8)

Number	Title	Issue Date
9034415	Surgical needle coatings and methods	2015/05/19
9221075	Surgical needle coatings and methods	2015/12/29
9259219	Surgical needle coatings and methods	2016/02/16
9266145	Surgical needle coatings and methods	2016/02/23
9332982	Surgical needle coatings and methods	2016/05/10
11197666	Surgical coated needles	2021/12/14
11717284	Surgical needle coatings and methods	2023/08/08
11832811	Surgical coated needles	2023/12/05

C.R. Bard (7)

Number	Title	Issue Date
10857324	Urinary catheter	2020/12/08
10874825	Urinary catheter	2020/12/29
11850370	Urinary catheter	2023/12/26
12589218	Intermittent-catheter assembly and methods thereof	2026/03/31
12611519	Intermittent-catheter assembly and methods thereof	2026/04/28
12691250	Intermittent-catheter assemblies and methods thereof	2026/07/28
12697467	Urinary catheter	2026/08/04

Medtronic (6)

Number	Title	Issue Date
7442205	Stents and methods for preparing stents from wires having hydrogel coating layers thereon	2008/10/28
8591531	Mesh pouches for implantable medical devices	2013/11/26
8636753	Temporarily stiffened mesh prostheses	2014/01/28
9023114	Resorbable pouches for implantable medical devices	2015/05/05
9848955	Resorbable pouches for implantable medical devices	2017/12/26
10765500	Temporarily stiffened mesh prostheses	2020/09/08

IPXMEDICAL, LLC (6)

Number	Title	Issue Date
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8287590	Medicated stent having multi-layer polymer coating	2012/10/16
8287590	Medicated stent having multi-layer polymer coating	2012/10/16

Pfizer (5)

Number	Title	Issue Date
7108701	Drug releasing anastomosis devices and methods for treating anastomotic sites	2006/09/19
7261735	Local drug delivery devices and methods for maintaining the drug coatings thereon	2007/08/28
7300662	Drug/drug delivery systems for the prevention and treatment of vascular disease	2007/11/27
8182527	Heparin barrier coating for controlled drug release	2012/05/22
8236048	Drug/drug delivery systems for the prevention and treatment of vascular disease	2012/08/07

Ethicon (4)

Number	Title	Issue Date
7041088	Medical devices having durable and lubricious polymeric coating	2006/05/09
7056550	Medical devices, drug coatings and methods for maintaining the drug coatings thereon	2006/06/06
10004494	Surgical needle coatings and methods	2018/06/26
10939907	Surgical needle coatings and methods	2021/03/09

cardinal health switzerland 515 (4)

Number	Title	Issue Date
7195640	Coated medical devices for the treatment of vulnerable plaque	2007/03/27
7217286	Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent	2007/05/15
7223286	Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent	2007/05/29
7229473	Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent	2007/06/12

Boston Scientific (4)

Number	Title	Issue Date
7335264	Differentially coated medical devices, system for differentially coating medical devices, and coating method	2008/02/26
7488313	Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment	2009/02/10
7674251	Medical devices including aerated adhesive bonds and methods of forming the same	2010/03/09
8043278	Medical devices including aerated adhesive bonds and methods of forming the same	2011/10/25

Hollister (3)

Number	Title	Issue Date
10617789	Hydrophilic coatings and methods of forming the same	2020/04/14
11623020	Hydrophilic coatings and methods of forming the same	2023/04/11
12364789	Hydrophilic coatings and methods of forming the same	2025/07/22

Corning (3)

Number	Title	Issue Date
8475886	Methods for producing surfaces that resist non-specific protein binding and cell attachment	2013/07/02
8652584	Methods for producing surfaces that resist non-specific protein binding and cell attachment	2014/02/18
9945849	Methods for producing surfaces that resist non-specific protein binding and cell attachment	2018/04/17

Cochlear (3)

Number	Title	Issue Date
8460746	Method of forming insulated conductive element having a substantially continuous barrier layer formed via relative motion during deposition	2013/06/11
8545926	Method of forming insulated conductive element having substantially continuously coated sections separated by uncoated gaps	2013/10/01
8726492	Insulated conductive element having a substantially continuous barrier layer formed through multiple coatings	2014/05/20

W. L. Gore & associates (2)

Number	Title	Issue Date
8048440	Thermoplastic fluoropolymer-coated medical devices	2011/11/01
8609125	Thermoplastic fluoropolymer-coated medical devices	2013/12/17

SurModics (2)

Number	Title	Issue Date
7691476	Hydrophilic polymeric coatings for medical articles	2010/04/06
8163327	Hydrophilic polymeric coatings for medical articles	2012/04/24

Alcon (1)

Number	Title	Issue Date
11001647	Soft silicone medical devices	2021/05/11

BioTronik Mess-und Therapiegeraete (1)

Number	Title	Issue Date
10709554	Heart valve prosthesis for controlled thrombus development	2020/07/14

advanced cardiocasvular systems (1)

Number	Title	Issue Date
7967998	Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability	2011/06/28

Aesculap & Co. (1)

Number	Title	Issue Date
8790389	Tubular colored vessel prosthesis and use thereof in surgery	2014/07/29

Endovascular Devices (1)

Number	Title	Issue Date
7396538	Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device	2008/07/08

abbott cardiovasular systems (1)

Number	Title	Issue Date
8109904	Drug delivery medical devices	2012/02/07

SICPA (1)

Number	Title	Issue Date
10711168	Process for assembling elements containing biological substances	2020/07/14

Shimadzu (1)

Number	Title	Issue Date
7175812	Automatic sampler and needle for the same	2007/02/13

corticalis (1)

Number	Title	Issue Date
9629941	Hydrogel coated scaffold	2017/04/25

COVALON technology (1)

Number	Title	Issue Date
6808738	Method of making anti-microbial polymeric surfaces	2004/10/26

Abbott Cardiocascular Systems (1)

Number	Title	Issue Date
8758801	Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages	2014/06/24

Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
427	2.24	Emerging	Average	Seminal	Medium	Average	29.4
523	113	Stable	Sustaining	Seminal	Medium	Average	37.5
623	1.46	Emerging	Average	Seminal	Medium High	Rapid	19.0
623	23.59	Emerging	Average	Seminal	Medium	Rapid	24.4