Graft polymerization of substrate surfaces

Overview

Information

Number: 6358557
Application: 09/394577
Filing date: 09/10/1999
Issue date: 03/19/2002
Inventor(s): Guo-Bin Wang, Xianping Zhang

US Classification: 427/2.24; 427/2.25; 427/2.28; 427/2.3; 427/2.31; 427/301; 427/302; 427/303; 427/372.2; 427/399; 427/400; 427/487

Citations

SurModics (2)

Number	Title	Issue Date
5002582	Preparation of polymeric surfaces via covalently attaching polymers	1991/03/26
5741551	Preparation of polymeric surfaces	1998/04/21

Angiotech International (2)

Number	Title	Issue Date
5069899	Anti-thrombogenic, anti-microbial compositions containing heparin	1991/12/03
5525348	Coating compositions comprising pharmaceutical agents	1996/06/11

Advanced Surface Technology (2)

Number	Title	Issue Date
5211993	Method of making novel separation media	1993/05/18
5447799	Polymerization process	1995/09/05

Conor Medsystems (1)

Number	Title	Issue Date
6013855	Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces	2000/01/11

Edwards Lifesciences (1)

Number	Title	Issue Date
4589964	Process for graft copolymerization of a pre-formed substrate	1986/05/20

SECRETARY OF STATE FOR DEFENSE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND THE; ENGLAND (1)

Number	Title	Issue Date
4377010	Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid	1983/03/22

Biocompatibles UK (1)

Number	Title	Issue Date
5453467	Polymer treatments	1995/09/26

JMS Co. (1)

Number	Title	Issue Date
4743258	Polymer materials for vascular prostheses	1988/05/10

University of Akron, The (1)

Number	Title	Issue Date
5663237	Graft copolymerization in supercritical media	1997/09/02

Medtronic (1)

Number	Title	Issue Date
5782908	Biocompatible medical article and method	1998/07/21

University of Medicine and Dentistry of New Jersey (1)

Number	Title	Issue Date
4442133	Antibiotic bonding of vascular prostheses and other implants	1984/04/10

Teijin (1)

Number	Title	Issue Date
4331697	Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative	1982/05/25

CIBA Vision (1)

Number	Title	Issue Date
4978481	Process for the encapsulation of preformed substrates by graft copolymerization	1990/12/18

INSTITUTE FOR POLYMER RESEARCH, DRESDEN (1)

Number	Title	Issue Date
6096369	Process for hydrophilicizing the surface of polymeric substrates with a macroinitiator as primer	2000/08/01

Abstract

Abstract

The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly usefull as medical products such as catheters.

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
427	2.24	Emerging	Average	Seminal	Medium High	Average	39.7
427	2.25	Emerging	Average	Average	Medium High	Average	38.7
427	2.28	Stable	Average	Average	Medium	Average	53.1
427	2.3	Stable	Average	Average	Medium	Average	57.4
427	2.31	Stable	Average	Average	Medium	Average	55.3
427	301	Emerging	Sustaining	Seminal	Medium	Average	38.8
427	302	Declining	Sustaining	Average	Medium	Average	69.2
427	303	Stable	Sustaining	Seminal	Medium	Average	71.1
427	372.2	Emerging	Sustaining	Seminal	Medium	Average	51.7
427	399	Declining	Sustaining	Average	Medium	Slow	77.0
427	400	Declining	Sustaining	Average	Medium	Slow	77.7
427	487	Emerging	Sustaining	Seminal	Medium	Average	44.3