Ecarin prothrombin protease and methods
Overview
Abstract
Abstract
New forms of ecarin, a procoagulant protein from Echis carinatus venom, are described, as are polynucleotides encoding the new proteins, methods for production of the new proteins, and methods for activation of prothrombin using the new proteins. The new ecarins comprise a serine at position 396 of the protein. The new proteins may be used for activation of prothrombin, and are particularly useful for the production of recombinant thrombin.
Assignees with Similar Patents
Referenced by
- Medimmune (5)
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| Number |
Title |
Issue Date |
| 7842477 |
Methods for producing gamma-carboxylated proteins |
2010/11/30 |
| 7989193 |
Compositions and methods for producing gamma-carboxylated proteins |
2011/08/02 |
| 8206967 |
Method for production of recombinant human thrombin |
2012/06/26 |
| 8304224 |
Compositions and methods relating to proteins requiring gamma-carboxylation |
2012/11/06 |
| 8697440 |
Compositions and methods for producing gamma-carboxylated proteins |
2014/04/15 |
- Baxter International (1)
-
| Number |
Title |
Issue Date |
| 8759066 |
Thrombin activator compositions and methods of making and using the same |
2014/06/24 |
- ARONORA, LLC (1)
-
| Number |
Title |
Issue Date |
| 8940297 |
Expression of thrombin variants |
2015/01/27 |
Tech Analysis
| Class |
Subclass |
Type |
Reference Factor |
Citation Factor |
Strength |
Grant time |
Early grant (%) |
|
435
|
212
|
Stable |
Novel |
Average |
Medium |
Average |
25.8 |
|
435
|
214
|
Stable |
Novel |
Average |
Medium |
Average |
25.2 |
|
435
|
226
|
Emerging |
Novel |
Average |
Medium High |
Average |
26.6 |
|
435
|
68.1
|
Emerging |
Novel |
Average |
Medium High |
Average |
26.6 |