Methods for the production of gelatin and full-length triple helical collagen in recombinant cells

Overview

Information

Number: 6428978
Application: 09/289578
Filing date: 04/09/1999
Issue date: 08/06/2002
Inventor(s): David R. Olsen, Robert Chang, Hugh McMullin, Ronald A. Hitzeman, George Chisholm

US Classification: 435/69.1; 530/350; 530/354; 530/356; 536/23.1; 536/24.3

Citations

Thomas Jefferson University (3)

Number	Title	Issue Date
5593859	Synthesis of human procollagens and collagens in recombinant DNA systems	1997/01/14
5663482	Transgenic mice expressing a mutated human collagen gene	1997/09/02
5807981	Peptides which are cleaved by C-proteinase	1998/09/15

Fibrogen (3)

Number	Title	Issue Date
5593859	Synthesis of human procollagens and collagens in recombinant DNA systems	1997/01/14
5807981	Peptides which are cleaved by C-proteinase	1998/09/15
6020193	Recombinant C-proteinase and processes, methods and uses thereof	2000/02/01

Angiotech International (2)

Number	Title	Issue Date
5667839	Human recombinant collagen in the milk of transgenic animals	1997/09/16
5328955	Collagen-polymer conjugates	1994/07/12

Organogenesis (2)

Number	Title	Issue Date
5256418	Collagen constructs	1993/10/26
5830708	Methods for production of a naturally secreted extracellular matrix	1998/11/03

Corning (1)

Number	Title	Issue Date
5731417	Cell culture substrates and method of making	1998/03/24

Cohesion Technologies (1)

Number	Title	Issue Date
5428022	Composition of low type III content human placental collagen	1995/06/27

Research Development Foundation (1)

Number	Title	Issue Date
5002071	Injectable soft tissue augmentation materials from the placenta and their method of manufacture	1991/03/26

SURGICAL SPECIALTIES (1)

Number	Title	Issue Date
6096309	Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof	2000/08/01

Washington Research Foundation (1)

Number	Title	Issue Date
5962639	Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites	1999/10/05

Bioscience Consultants (1)

Number	Title	Issue Date
5714582	Invertebrate type V telopeptide collagen, methods of making, and use thereof	1998/02/03

Spine Wave (1)

Number	Title	Issue Date
5496712	High molecular weight collagen-like protein polymers	1996/03/05

Academy of Finland (1)

Number	Title	Issue Date
5593859	Synthesis of human procollagens and collagens in recombinant DNA systems	1997/01/14

Wisconsin Alumni Research Foundation (1)

Number	Title	Issue Date
6037139	System for assaying modulators of procollagen maturation	2000/03/14

Abstract

Abstract

Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are introduced into recombinant host cells and expressed. Trimeric collagen is recovered from the recombinant host cells.

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
435	69.1	Emerging	Sustaining	Seminal	Medium	Average	53.2
530	350	Emerging	Sustaining	Seminal	Medium	Average	50.9
530	354	Declining	Sustaining	Average	Medium	Slow	78.2
530	356	Stable	Sustaining	Average	Medium	Average	70.3
536	23.1	Emerging	Sustaining	Seminal	Medium	Average	54.1
536	24.3	Emerging	Sustaining	Seminal	Medium	Average	56.0