Fibrin sealants or adhesives comprising a hyaluronic acid derivative material

Overview

Information

Number
6503527
Application
09/554745
Filing date
08/14/2000
Issue date
01/07/2003
Inventor(s)
Elaine Whitmore, Marc R. Paquin
US Classification
424/422; 424/424; 424/425; 424/426; 424/443; 424/444; 514/13.5; 514/13.6; 514/54; 514/55; 514/56; 606/214; 606/215
View at USPTO

Citations

Fidia Farmaceutici S.p.A. (3)
Angiotech International (2)
Immuno (1)
Regents of the University of California, The (1)
FIDIA S.p.A. (1)
Aventis Behring (1)
JONAS WADSTROM (1)

Abstract

Abstract

A fibrin adhesive or sealant composition comprising a biocompatible, bioabsorbable hyaluronic acid material, chitin material, or chitosan material to which fibrinogen and a fibrinogen-cleaving agent are applied, along with other components such as additional coagulation factors, anti-fibrinolytics, stabilizers and biologically active substances. The fibrinogen, fibrinogen-cleaving agent and other components can take the form of dry preparation, an aqueous or nonaqueous preparation, or a combination thereof. Such a composition can be placed directly on, around, or within a wound site and is fully reabsorbed into the body.

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PAUZA, KEVIN (5)
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RIKEN (1)
Angiotech International (1)
Orthovita (1)

Tech Analysis

Class Subclass Type Reference Factor Citation Factor Strength Grant time Early grant (%)
424 422 Emerging Average Average Medium Average 40.2
424 424 Stable Average Average Medium Average 44.1
424 425 Stable Average Average Medium Average 39.4
424 426 Emerging Average Average Medium Average 39.7
424 443 Emerging Average Seminal Medium Average 42.0
424 444 Stable Average Average Medium Average 48.4
514 13.5 Stable Sustaining Average Medium Average 37.1
514 13.6 Stable Average Average Medium Average 37.5
514 54 Emerging Sustaining Average Medium Average 38.4
514 55 Stable Average Seminal Medium Average 39.6
514 56 Stable Average Average Medium Average 41.8
606 214 Emerging Novel Seminal High Average 25.9
606 215 Emerging Novel Average Medium High Average 35.5