Surgically implanted devices having reduced scar tissue formation

Overview

Information

Number: 6534693
Application: 09/772693
Filing date: 01/31/2001
Issue date: 03/18/2003
Inventor(s): Robert E. Fischell, David R. Fischell, Tim A. Fischell, Scott J. S. Fischell

US Classification: 602/43; 602/48

Citations

NA (4)

Number	Title	Issue Date
6273908	Stents	2001/08/14
4865031	Fabric and method of use for treatment of scars	1989/09/12
5693607	Uses of TGF-.beta. receptor fragment as a therapeutic agent	1997/12/02
4863457	Drug delivery device	1989/09/05

Pfizer (3)

Number	Title	Issue Date
5151413	Rapamycin acetals as immunosuppressant and antifungal agents	1992/09/29
5496832	Method of treating cardiac inflammatory disease	1996/03/05
5516781	Method of treating restenosis with rapamycin	1996/05/14

Houston Biotechnology (2)

Number	Title	Issue Date
6063396	Methods and compositions for the modulation of cell proliferation and wound healing	2000/05/16
5618553	Methods and compositions for the modulation of cell proliferation and wound healing	1997/04/08

American National Red Cross (2)

Number	Title	Issue Date
6124273	Chitin hydrogels, methods of their production and use	2000/09/26
6117425	Supplemented and unsupplemented tissue sealants, method of their production and use	2000/09/12

Abbott Laboratories (2)

Number	Title	Issue Date
6015815	Tetrazole-containing rapamycin analogs with shortened half-lives	2000/01/18
5708002	Macrocyclic immunomodulators	1998/01/13

Novartis (2)

Number	Title	Issue Date
5912253	Rapamycin derivatives	1999/06/15
6200985	Rapamycin derivatives	2001/03/13

REGENTS OF THE UNIVERSITY OF MICHIGAN, THE (1)

Number	Title	Issue Date
6143037	Compositions and methods for coating medical devices	2000/11/07

Boston Scientific (1)

Number	Title	Issue Date
6221099	Tubular medical prosthesis	2001/04/24

HEWITT, CHARLES W. (1)

Number	Title	Issue Date
5540931	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants	1996/07/30

General Hospital (1)

Number	Title	Issue Date
5912224	Methods and compositions for enhancing cellular response to TGF-.beta. ligands	1999/06/15

Chitogenics (1)

Number	Title	Issue Date
6124273	Chitin hydrogels, methods of their production and use	2000/09/26

Alcon Manufacturing, (1)

Number	Title	Issue Date
5624893	Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation	1997/04/29

ALABAMA AT BIRMINGHAM, UNIVERSITY OF (1)

Number	Title	Issue Date
5981568	Therapeutic inhibitor of vascular smooth muscle cells	1999/11/09

University of Louisville Research Foundation (1)

Number	Title	Issue Date
5387589	Method of treating ocular inflammation	1995/02/07

Genzyme (1)

Number	Title	Issue Date
5843156	Local polymeric gel cellular therapy	1998/12/01

NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (1)

Number	Title	Issue Date
6060474	Method for preventing scar tissue formation	2000/05/09

BLACK, KIRBY S. (1)

Number	Title	Issue Date
5540931	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants	1996/07/30

Colla-Gene (1)

Number	Title	Issue Date
5798334	Pharmaceutical compositions for scarless tissue repair and regeneration and methods related thereto	1998/08/25

C.R. Bard (1)

Number	Title	Issue Date
4895566	Coating medical devices with cationic antibiotics	1990/01/23

President And Fellows Of Harvard College (1)

Number	Title	Issue Date
4952403	Implants for the promotion of healing of meniscal tissue	1990/08/28

Coalition for Hemophilia B (1)

Number	Title	Issue Date
6124273	Chitin hydrogels, methods of their production and use	2000/09/26

Trustees of Boston University (1)

Number	Title	Issue Date
5756673	Regulation of smooth muscle cell proliferation	1998/05/26

Arch Development (1)

Number	Title	Issue Date
5552162	Method for improvement of scar size and appearance	1996/09/03

tin dba temple inland (1)

Number	Title	Issue Date
5795286	Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation	1998/08/18

Abstract

Abstract

This invention is an anti-proliferative drug placed onto or within a sterile sheet or mesh that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This mesh or gauze onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL.TM. absorbable hemostat gauze-like sheet with an anti-proliferative drug such as Rapamycin or Taxol, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions. Another embodiment of this invention is an anti-proliferative drug attached to a bandage that is placed onto a cut in the skin to decrease scar tissue formation. Still another embodiment of the invention is an anti-proliferative drug that is attached to a surgical suture or coated onto a surgical staple both of which are used for connecting human tissues. The suture or staple then being more capable for decreasing cellular proliferation where the suture or staple material passes through the human tissue.

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
602	43	Stable	Average	Seminal	Medium	Average	33.3
602	48	Stable	Sustaining	Seminal	Medium	Average	35.2