Targeted therapeutic agent release devices and methods of making and using the same

Overview

Information

Number: 8101200
Application: 09/834307
Filing date: 04/12/2001
Issue date: 01/24/2012
Inventor(s): Richard J. Whitbourne, Daniel Hullihen, Michael R. Violante, Frank Guo-Bin Wang, Xianping Zhang

US Classification: 424/422; 424/423; 424/424; 424/426

Citations

ALABAMA AT BIRMINGHAM, UNIVERSITY OF (8)

Number	Title	Issue Date
6515009	Therapeutic inhibitor of vascular smooth muscle cells	2003/02/04
6491938	Therapeutic inhibitor of vascular smooth muscle cells	2002/12/10
6599928	Therapeutic inhibitor of vascular smooth muscle cells	2003/07/29
6306421	Therapeutic inhibitor of vascular smooth muscle cells	2001/10/23
6268390	Therapeutic inhibitor of vascular smooth muscle cells	2001/07/31
6171609	Therapeutic inhibitor of vascular smooth muscle cells	2001/01/09
6074659	Therapeutic inhibitor of vascular smooth muscle cells	2000/06/13
5733925	Therapeutic inhibitor of vascular smooth muscle cells	1998/03/31

Advanced cardiovascular Systems (6)

Number	Title	Issue Date
6254632	Implantable medical device having protruding surface structures for drug delivery and cover attachment	2001/07/03
6663662	Diffusion barrier layer for implantable devices	2003/12/16
5707385	Drug loaded elastic membrane and method for delivery	1998/01/13
5843172	Porous medicated stent	1998/12/01
6395326	Apparatus and method for depositing a coating onto a surface of a prosthesis	2002/05/28
6616765	Apparatus and method for depositing a coating onto a surface of a prosthesis	2003/09/09

Angiotech International (5)

Number	Title	Issue Date
5525348	Coating compositions comprising pharmaceutical agents	1996/06/11
5331027	Lubricious hydrophilic coating, resistant to wet abrasion	1994/07/19
5716981	Anti-angiogenic compositions and methods of use	1998/02/10
5069899	Anti-thrombogenic, anti-microbial compositions containing heparin	1991/12/03
5001009	Lubricious hydrophilic composite coated on substrates	1991/03/19

SURGICAL SPECIALTIES (4)

Number	Title	Issue Date
5997517	Bonding layers for medical device surface coatings	1999/12/07
6306176	Bonding layers for medical device surface coatings	2001/10/23
6110483	Adherent, flexible hydrogel and medicated coatings	2000/08/29
5800412	Hydrophilic coatings with hydrating agents	1998/09/01

Boston Scientific (4)

Number	Title	Issue Date
7041130	Stent for controlled release of drug	2006/05/09
6783543	Intravascular stent with increasing coating retaining capacity	2004/08/31
5972027	Porous stent drug delivery system	1999/10/26
7052488	Implantable drug delivery device	2006/05/30

Innovational (3)

Number	Title	Issue Date
6562065	Expandable medical device with beneficial agent delivery mechanism	2003/05/13
6241762	Expandable medical device with ductile hinges	2001/06/05
6293967	Expandable medical device with ductile hinges	2001/09/25

Dexcel Pharma Technologies (2)

Number	Title	Issue Date
6231888	Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps	2001/05/15
5866619	Colonic drug delivery system	1999/02/02

IPXMEDICAL, LLC (2)

Number	Title	Issue Date
6515016	Composition and methods of paclitaxel for treating psoriasis	2003/02/04
6515016	Composition and methods of paclitaxel for treating psoriasis	2003/02/04

University of Kentucky Research Foundation (2)

Number	Title	Issue Date
6001386	Implantable controlled release device to deliver drugs directly to an internal portion of the body	1999/12/14
5977315	Murine anti-idiotype antibody 3H1	1999/11/02

ALZA (2)

Number	Title	Issue Date
4723957	System for delivering drug with enhanced bioacceptability	1988/02/09
6071305	Directional drug delivery stent and method of use	2000/06/06

Duke University (2)

Number	Title	Issue Date
5059211	Absorbable vascular stent	1991/10/22
5306286	Absorbable stent	1994/04/26

Cordis (2)

Number	Title	Issue Date
6273913	Modified stent useful for delivery of drugs along stent strut	2001/08/14
5882335	Retrievable drug delivery stent	1999/03/16

MicroChips (2)

Number	Title	Issue Date
6656162	Implantable drug delivery stents	2003/12/02
6491666	Microfabricated devices for the delivery of molecules into a carrier fluid	2002/12/10

The United States of America as represented by the Department of Health (1)

Number	Title	Issue Date
5616608	Method of treating atherosclerosis or restenosis using microtubule stabilizing agent	1997/04/01

Angstrom Pharmaceuticals (1)

Number	Title	Issue Date
5994309	Anti-invasive and anti-angiogenic compositions and methods	1999/11/30

BTG International (1)

Number	Title	Issue Date
5294448	Delayed release formulations	1994/03/15

Massachusetts Institute Of Technology (1)

Number	Title	Issue Date
5797898	Microchip drug delivery devices	1998/08/25

ADVANCED LASER APPLICATIONS (1)

Number	Title	Issue Date
7135039	Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof	2006/11/14

Becton, Dickinson and (1)

Number	Title	Issue Date
5589120	Process of making a shaped tip on a catheter	1996/12/31

PG-TXL (1)

Number	Title	Issue Date
5977163	Water soluble paclitaxel prodrugs	1999/11/02

BIOADVANCES, (1)

Number	Title	Issue Date
5840329	Pulsatile drug delivery system	1998/11/24

Scimed Life Systems (1)

Number	Title	Issue Date
6335029	Polymeric coatings for controlled delivery of active agents	2002/01/01

HEALTH AND HUMAN SERVICES, UNITED STATES OF AMERICA, THE, AS REPRESENTED BY THE SECRETARY (1)

Number	Title	Issue Date
6403635	Method of treating atherosclerosis or restenosis using microtubule stabilizing agent	2002/06/11

C.R. Bard (1)

Number	Title	Issue Date
4531933	Helical ureteral stent	1985/07/30

cid s p a (1)

Number	Title	Issue Date
6699281	Angioplasty stents	2004/03/02

Focal (1)

Number	Title	Issue Date
5779673	Devices and methods for application of intraluminal photopolymerized gels	1998/07/14

COOK MEDICAL TECHNOLOGIES (1)

Number	Title	Issue Date
6096070	Coated implantable medical device	2000/08/01

Emory University (1)

Number	Title	Issue Date
5523092	Device for local drug delivery and methods for using the same	1996/06/04

NA (1)

Number	Title	Issue Date
6273908	Stents	2001/08/14

Syngenta (1)

Number	Title	Issue Date
5660829	Process for antibody directed enzyme prodrug therapy	1997/08/26

Target Therapeutics (1)

Number	Title	Issue Date
5980550	Water-soluble coating for bioactive vasoocclusive devices	1999/11/09

Abstract

Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.

Assignees with Similar Patents

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Number	Title
101151555	Anti-angiogenic compositions and methods of use
7820193	Anti-angiogenic compositions and methods of use
102512474	ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE
102580580	ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE
102633795	MEDICATED STENT HAVING MULTI-LAYER POLYMER COATING
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Boston Scientific (10)

Number	Title
101857019	STENT WITH UNCONNECTED STENT SEGMENTS
7906133	Optimized dosing for drug coated stents
102002997	Medical devices having bioerodable layers for the release of therapeutic agents
6258121	Stent coating
102267289	Drug-Coated Medical Devices for Differential Drug Release
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103016826	LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS
6908622	Optimized dosing for drug coated stents
103187562	LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS
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Medtronic (6)

Number	Title
6918929	Drug-polymer coated stent with pegylated styrenic block copolymers
100698632	Drug-polymer coated stent with polysulfone and styrenic block copolymer
7144419	Drug-polymer coated stent with blended phenoxy and styrenic block copolymers
7815962	Coated stent with evenly distributed therapeutic agent
101840477	Coated Stent With Evenly Distributed Therapeutic Agent
7419696	Medical devices for delivering a therapeutic agent and method of preparation

Conor Medsystems (6)

Number	Title
101982575	Methods and Devices for Reducing Tissue Damage After Ischemic Injury
101582353	Methods and Devices for Reducing Tissue Damage After Ischemic Injury
101560264	Drug Delivery Stent with Extended In Vivo Drug Release
101191393	Methods of delivering anti-restenotic agents from a stent
100890980	Bioresorbable stent delivery system
100696671	Drug delivery device and method for bi-directional drug delivery

NA (6)

Number	Title
102287632	Drug Coated Stent Having a Surface Treatment and Method of Manufacturing
102497178	Medical Devices, Drug Coatings And Methods For Maintaining The Drug Coatings Thereon
102562955	ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES
102603381	ADHESION PROMOTING PRIMER FOR COATED SURFACES
102643989	ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES
102679812	ADHESION PROMOTING PRIMER FOR COATED SURFACES

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Hollister (1)

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autotelic (1)

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9763892	Immediate release phospholipid-coated therapeutic agent nanoparticles and related methods	2017/09/19

Minnesota Mining and Manufacturing (1)

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Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	422	Emerging	Sustaining	Average	Medium Low	Slow	99.6
424	423	Emerging	Sustaining	Average	Medium	Slow	99.3
424	424	Stable	Sustaining	Not Seminal	Medium Low	Slow	99.7
424	426	Emerging	Sustaining	Average	Medium Low	Slow	99.4